Interleukin 10 polymorphisms in ankylosing spondylitis
| Autor: | Daniel E. Weeks, V. Goedecke, Jonathan Wilson, A. M. Crane, Matthew A. Brown, E. Jaakkola, Jaakko Tuomilehto, W. Kaluza, Markku J Kauppi, Kari Laiho, B P Wordsworth, K. Kaarela |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
musculoskeletal diseases
Immunology chemical and pharmacologic phenomena Single-nucleotide polymorphism Biology Polymorphism Single Nucleotide immune system diseases parasitic diseases Genetics medicine SNP Humans Spondylitis Ankylosing Allele Spondylitis Genetics (clinical) Alleles Genetic association Ankylosing spondylitis Polymorphism Genetic Haplotype hemic and immune systems medicine.disease Interleukin-10 BASFI Microsatellite Repeats |
| DOI: | 10.1038/sj.gene.6363930 |
| Popis: | Genetic polymorphisms of the IL10 promoter region have been implicated in many autoimmune diseases, including seronegative spondyloarthropathies. We studied three SNPs (IL10-1087, -824, and -597) and two microsatellites (IL10R and IL10G) lying within the promoter region of IL10 for association with susceptibility to and clinical manifestations of ankylosing spondylitis (AS), a common form of spondyloarthritis. Four hundred and sixty-eight individuals from 182 Finnish families affected with AS were studied. No association between individual IL10 promoter region polymorphisms or marker haplotype was observed with susceptibility to AS, but weak association was noted between the IL10-597 and -824 SNPs and age of disease onset (P=0.01 for each SNP). The IL10.G4 allele was associated with BASFI (corrected for disease duration) (P=0.03). We conclude that IL10 promoter polymorphisms have no significant effect on susceptibility to AS, but may play a minor role in determining age of disease onset and disease severity. |
| Databáze: | OpenAIRE |
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