Physiological regulation of eukaryotic topoisomerase II
| Autor: | Richard J. Isaacs, Charles Redwood, Nicholas J. Wells, M. Ines Sandri, Ian D. Hickson, Sally L. Davies |
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| Rok vydání: | 1998 |
| Předmět: |
Transcription
Genetic Molecular Sequence Data Biophysics Biology Biochemistry Gene Expression Regulation Enzymologic chemistry.chemical_compound Structural Biology Transcription (biology) Gene expression Genetics Animals Phosphorylation Promoter Regions Genetic Protein kinase A Mammals Regulation of gene expression Base Sequence Kinase Topoisomerase Cell Cycle DNA Sequence Analysis DNA Cell biology DNA Topoisomerases Type II Eukaryotic Cells chemistry biology.protein Protein Kinases Protein Processing Post-Translational |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1400:121-137 |
| ISSN: | 0167-4781 |
| DOI: | 10.1016/s0167-4781(98)00131-6 |
| Popis: | Topoisomerase II is an essential enzyme in all organisms with several independent roles in DNA metabolism. In this article we review our knowledge on the regulation of the expression and catalytic activity of topoisomerase II in both lower and higher eukaryotes. Current data indicate that the regulation of topoisomerase II gene expression is complex, with positive and negative controls in evidence at the level of both promoter activity and mRNA stability. Similarly, the activity of the mature enzyme can be regulated by the action of several different protein kinases. Of particular interest is the cell cycle-dependent phosphorylation of topoisomerase II, including multiple, mitosis-specific modifications, which are proposed to regulate the essential chromosome decatenation activity of the enzyme. |
| Databáze: | OpenAIRE |
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