Chronic osteo-articular changes in patients with sickle cell disease
| Autor: | Ana Paula Teixeira dos Santos, Gilberto de Araújo Pereira, Taciana Fernandes Araújo Ferreira, Alexandra Silva Leal, Helio Moraes-Souza, Sheila Soares Silva |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male lcsh:Immunologic diseases. Allergy medicine.medical_specialty lcsh:Diseases of the musculoskeletal system Adolescent Anemia Hemoglobin Sickle Skin Pigmentation Anemia Sickle Cell Disease Osteoarthritis Gastroenterology Young Adult 03 medical and health sciences 0302 clinical medicine Rheumatology Antisickling Agents Internal medicine medicine Humans Hydroxyurea Femur 030203 arthritis & rheumatology business.industry Osteopenia Sickle cell disease Osteonecrosis medicine.disease Abnormal hemoglobin Cross-Sectional Studies Hemoglobinopathy 030220 oncology & carcinogenesis Female lcsh:RC925-935 lcsh:RC581-607 business |
| Zdroj: | Advances in Rheumatology, Volume: 61, Article number: 11, Published: 01 MAR 2021 Advances in Rheumatology, Vol 61, Iss 1, Pp 1-5 (2021) |
| Popis: | Background Sickle cell disease (SCD) is an autosomal recessive genetic disease in which a mutation occurs in the β-globin chain gene, resulting in abnormal hemoglobin levels. In an environment with reduced oxygen concentration, red blood cells change their conformation, resulting in chronic hemolysis and consequent anemia and vaso-occlusive crises with injuries to several organs, with a significant impairment of the osteoarticular system. This study aimed to verify the chronic osteoarticular alterations and their association with clinical and laboratory characteristics of patients with SCD with a more severe phenotype (SS and Sβ0), on a steady-state fasis. Methods Fifty-five patients were referred to a medical consultation with a specialized assessment of the locomotor system, followed by laboratory tests and radiographic examinations. Results In total, 74.5% patients had hemoglobinopathy SS; 67.3% were female; and 78.2% were non-whites. The mean patient age was 30.5 years. Most patients (61.8%) reported up to three crises per year, with a predominance of high-intensity pain (65.5%). Radiographic alterations were present in 80% patients. A total of 140 lesions were identified, most which were located in the spine, femur, and shoulders. Most lesions were osteonecrosis and osteoarthritis and were statistically associated with the non-use of hydroxyurea. Conclusions There was a high prevalence of chronic osteoarticular alterations, which was statistically associated only with the non-regular use of hydroxyurea. |
| Databáze: | OpenAIRE |
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