Liver‐Expressed Antimicrobial Peptide 2 antagonizes the insulinostatic effect of ghrelin in rat isolated pancreatic islets

Autor: Gérard Cros, Morgane Bayle, Jérémie Neasta, Catherine Oiry, Sylvie Peraldi-Roux, Guillaume Gautheron
Přispěvatelé: Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2021
Předmět:
medicine.medical_specialty
insulin secretion
[SDV]Life Sciences [q-bio]
Peptide
Liver-expressed antimicrobial peptide
Islets of Langerhans
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Animals
Insulin
Pharmacology (medical)
Receptors
Ghrelin
Receptor
LEAP2
islets of Langerhan
ComputingMilieux_MISCELLANEOUS
030304 developmental biology
Pharmacology
chemistry.chemical_classification
0303 health sciences
Chemistry
Pancreatic islets
digestive
oral
and skin physiology
[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism
Rats
Endocrinology
medicine.anatomical_structure
Liver
030220 oncology & carcinogenesis
ghrelin
[SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology
Ghrelin
Secretagogue
GHSR
Endogenous agonist
hormones
hormone substitutes
and hormone antagonists
Antimicrobial Cationic Peptides
Hormone
Zdroj: Fundamental and Clinical Pharmacology
Fundamental and Clinical Pharmacology, Wiley, 2021, ⟨10.1111/fcp.12722⟩
Fundamental and Clinical Pharmacology, Wiley, In press, ⟨10.1111/fcp.12722⟩
ISSN: 0767-3981
1472-8206
DOI: 10.1111/fcp.12722⟩
Popis: Background The hormone ghrelin is the endogenous agonist of the G-protein coupled receptor (GPCR) termed growth-hormone secretagogue receptor (GHSR). Ghrelin inhibits glucose-stimulated insulin secretion by activating pancreatic GHSR. Recently, Liver-Expressed Antimicrobial Peptide 2 (LEAP2) was recognized as an endogenous GHSR ligand that blocks ghrelin-induced actions. Nonetheless, the effect of LEAP2 on glucose-stimulated insulin secretion from pancreatic islets is unknown. Objectives We aimed at exploring the activity of LEAP2 on glucose-stimulated insulin secretion. Methods Islets of Langerhans isolated from rat pancreas were exposed to glucose in the presence or in the absence of LEAP2 and ghrelin and then insulin secretion was assayed. Results LEAP2 did not modulate glucose-stimulated insulin secretion. However, LEAP2 blocked the insulinostatic action of ghrelin. Conclusion Our data show that LEAP2 behaves as an antagonist of pancreatic GHSR.
Databáze: OpenAIRE
Externí odkaz: