LDL-cholesterol-lowering effect of a dietary supplement with plant extracts in subjects with moderate hypercholesterolemia

Autor: Sebastien Peltier, Marie-Josèphe Amiot, Stéphane Georgé, Jean-François Lescuyer, Nicolas N. Ogier, Matthieu Maillot, Marie Maraninchi, Cécilia Mallmann, Sophie Morange, Nicolas Cardinault
Přispěvatelé: Laboratoire LESCUYER, Nutrition, obésité et risque thrombotique (NORT), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Technique de la Conservation des Produits Agricoles (CTCPA), Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Laboratoire Lescuyer, Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), ProdInra, Migration
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Male
RED-YEAST-RICE
medicine.medical_treatment
[SDV]Life Sciences [q-bio]
Medicine (miscellaneous)
Ascorbic Acid
030204 cardiovascular system & hematology
chemistry.chemical_compound
Dietary supplement
0302 clinical medicine
Cynara scolymus
Malondialdehyde
Vitamin E
030212 general & internal medicine
Food science
Lipid-lowering plant extracts
Nutrition and Dietetics
Anticholesteremic Agents
PLASMA-CHOLESTEROL
food and beverages
Middle Aged
LIPID-PEROXIDATION
3. Good health
[SDV] Life Sciences [q-bio]
Biochemistry
PURPUREUS WENT RICE
Female
lipids (amino acids
peptides
and proteins)
Low-density-lipoprotein cholesterol
Fatty Alcohols
Adult
Hypercholesterolemia
LOW-DENSITY-LIPOPROTEIN
Biology
CONTROLLED-TRIAL
VITAMIN-E CONSUMPTION
Young Adult
03 medical and health sciences
Double-Blind Method
POLICOSANOL
medicine
Red yeast rice
Humans
CORONARY-HEART-DISEASE
Policosanols
Sugar
Triglycerides
Biological Products
Plant Extracts
Cholesterol
Cholesterol
HDL
Polyphenols
Cholesterol
LDL
Ascorbic acid
II HYPERCHOLESTEROLEMIA
Plant Leaves
chemistry
Polyphenol
Dietary Supplements
Zdroj: European Journal of Nutrition
European Journal of Nutrition, Springer Verlag, 2013, 52 (2), pp.547-557. ⟨10.1007/s00394-012-0357-x⟩
European Journal of Nutrition, 2013, 52 (2), pp.547-557. ⟨10.1007/s00394-012-0357-x⟩
ISSN: 1436-6207
1436-6215
Popis: International audience; Red yeast rice (RYR), sugar cane-derived policosanols (SCdP) and artichoke leaf extracts (ALEs) are currently incorporated alone or in combination into dietary supplements for their potential low-density-lipoprotein cholesterol (LDL-cholesterol)-lowering effects. Yet, there is no information supporting the efficacy of this association on the reduction in LDL-cholesterol. The main objective of this study was to investigate the effects of a new dietary supplement (DS) with RYR, SCdP and ALEs on LDL-cholesterol. In a double-blind, randomized, parallel controlled study, 39 subjects from 21 to 55 years with moderate hypercholesterolemia without drug treatment were assigned to 2 groups and then consumed either a DS containing RYR, SCdP and ALEs or a placebo over a 16-week period. Plasma concentrations of lipids [LDL-cholesterol, total cholesterol (TC), high-density-lipoprotein cholesterol (HDL-cholesterol), triacylglycerols (TG)] and plasma levels of vitamins C and E, total polyphenols and malondialdehyde were determined at baseline and after 4, 8, 12 and 16 weeks. LDL-cholesterol and TC were reduced by, respectively, 21.4 % (95 % CI, -13.3 to -24.9 %, p < 0.001) and 14.1 % (95 % CI, -10.1 to -18.0 %, p < 0.001) at week 16 in the DS group compared with baseline. Similar results were obtained at weeks 4, 8 and 12. TG decreased by 12.2 % after 16 weeks in the DS group (95 % CI: -24.4 to -0.1 %, p < 0.05). For the vitamin E/TC ratio, a difference was observed between groups at week 16 (p < 0.05). Other parameters were not modified. Daily consumption of this new DS decreased LDL-cholesterol and TC and is therefore an interesting, convenient aid in managing mild to moderate hypercholesterolemia.
Databáze: OpenAIRE
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