Hospitalisations related to systemic sclerosis and the impact of interstitial lung disease. Analysis of patients hospitalised at the University of Michigan, USA

Autor: Sankar, Shobana, Habib, Mirette, Jaafar, Sara, Nagaraja, Vivek, Roofeh, David, Young, Amber, Huang, Suiyuan, Khanna, Dinesh
Rok vydání: 2021
Předmět:
Zdroj: Clin Exp Rheumatol
ISSN: 1593-098X
0392-856X
DOI: 10.55563/clinexprheumatol/9ivp9g
Popis: OBJECTIVES: To determine the primary reason for hospitalizations in systemic sclerosis (SSc) and impact of underlying interstitial lung disease (ILD) in a tertiary scleroderma center. METHODS: A retrospective analysis on a subset of a scleroderma cohort from 2011 - 2019 was performed to assess causes for hospitalizations and mortality. A chart review was performed to extract demographics, primary reason for hospitalization and inpatient mortality. Admissions were classified as SSc (if hospitalization reason was related to primary organ dysfunction) and non-SSc related causes. RESULTS: The mean age of the cohort was 53.1 years, 78% were women, and the mean disease duration was 5.2 years. Among 484 patients, 182 (37.6%) were admitted for a total of 634 admissions. In 382 SSc-related admissions, pulmonary hypertension (12.0%) and gastrointestinal dysmotility (11.0%), were major causes of urgent admissions; management of digital vasculopathy (26.1%) was the major reason for elective admissions. In 252 non-SSc related admissions, infection (respiratory:11.5%, skin and soft tissue: 6.3%) was the major reason for urgent admissions, and elective surgery (21.4%) was the major reason for elective admissions. We found 65% of all patients had underlying ILD and a greater proportion of patients with ILD were hospitalized (122 patients). Overall inpatient mortality was 9.3% and the leading cause for mortality was progressive pulmonary hypertension. CONCLUSION: Among a large cohort of SSc patients who are followed at a tertiary scleroderma center, 37.6% had hospital admissions, while worsening pulmonary hypertension, ILD, cardiac involvement and infectious complications were the major cause of mortality and morbidity.
Databáze: OpenAIRE
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