Metabolism and disposition of juglone in male F344 rats
| Autor: | Leo T. Burka, E. H. Lebetkin, L.-J. Chen |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
Metabolic Clearance Rate Health Toxicology and Mutagenesis Administration Topical Administration Oral Urine Pharmacology Toxicology Kidney Biochemistry chemistry.chemical_compound Feces medicine Animals Tissue Distribution Chemistry General Medicine Metabolism Rats Inbred F344 Rats Cytosol medicine.anatomical_structure Liver Organ Specificity Injections Intravenous Microsome NAD+ kinase Juglone Naphthoquinones |
| Zdroj: | Xenobiotica; the fate of foreign compounds in biological systems. 35(10-11) |
| ISSN: | 0049-8254 |
| Popis: | The metabolism and disposition of 14C-labelled juglone in male F344 rats following oral, intravenous and dermal administration were studied. Approximately 40-50% of an oral dose (0.1 to 10 mg kg-1) and less than 20% of the dermal dose (4 mg kg-1) were absorbed within 24 h. Most of the oral dose was excreted in faeces and urine within 24 h and only 1-3% remained in the tissues. High concentrations of juglone-derived radioactivity were found in kidney for all three dosing routes. The accumulation in kidney can be attributed to covalent binding of juglone and/or metabolites to cytosolic protein. Five metabolites were identified in the urine of rats treated with an oral dose: 1,4,5-trihydroxynaphthalene di-glucuronide, 1,4,5-trihydroxynaphthalene mono-glucuronide mono-sulfate, 2-sulfo-2,3-dihydrojuglone, 4,8-dihydroxy-1-tetralone mono-glucuronide and 1,4,5-trihydroxynaphthalene mono-glucuronide. Liver microsomal incubations of juglone in the presence of NAD(P)H and UDP-glucuronic acid gave rise to two 1,4,5-trihydroxynaphthalene mono-glucuronides. |
| Databáze: | OpenAIRE |
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