Effect of Erythromycin on Myocardial Repolarization in Patients With Community-Acquired Pneumonia
| Autor: | Kdesh A, Manthous Ca, Yasick D, McPherson Ca, Bradley K, Yaylali Y |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Male medicine.medical_specialty Heart disease Administration Oral Erythromycin Torsades de pointes QT interval Coronary artery disease Community-acquired pneumonia Heart Conduction System Torsades de Pointes Internal medicine Pneumonia Bacterial medicine Humans Infusions Intravenous Aged Aged 80 and over Cumulative dose business.industry General Medicine Middle Aged medicine.disease Anti-Bacterial Agents Surgery Community-Acquired Infections Heart failure Cardiology Female business medicine.drug |
| Zdroj: | Southern Medical Journal. 92:1178-1182 |
| ISSN: | 0038-4348 |
| DOI: | 10.1097/00007611-199912000-00009 |
| Popis: | BACKGROUND Erythromycin has been associated with prolongation of myocardial repolarization and torsades de pointes (TdP). METHODS To determine the frequency, dose-response, and risk factors for erythromycin-associated prolongation of myocardial repolarization, we observed data of patients admitted to our hospital with pneumonia who were treated with erythromycin. RESULTS In 35 women and 28 men enrolled in this study, the QTc increased from 434 +/- 4 milliseconds at baseline to 464 +/- 5 milliseconds after receiving a cumulative dose of 3.2 +/- 0.2 g of erythromycin. Neither age, sex, presence of preexistent congestive heart failure/coronary artery disease, electrolyte values, nor cumulative dose of erythromycin was associated with QTc prolongation. In 27 patients who received intravenous erythromycin for 3 days, the QTc increased from 427 +/- 5 milliseconds before to 461 +/- 8 milliseconds at 24 hours but did not increase further by day 3 (457 +/- 10 milliseconds). No patient in this cohort had TdP. CONCLUSIONS Erythromycin therapy is associated with prolongation of myocardial repolarization that manifests after the first few doses in a majority of patients. |
| Databáze: | OpenAIRE |
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