The acute-phase response and associated lipoprotein abnormalities accompanying lymphoma
| Autor: | V G Cabana, J. D. Blackman, T. Mazzone |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Lymphoma B-Cell Apolipoprotein B Lipoproteins medicine.medical_treatment chemistry.chemical_compound Internal medicine Internal Medicine medicine Humans Serum amyloid A Acute-Phase Reaction Chemotherapy biology Cholesterol business.industry Acute-phase protein Middle Aged medicine.disease Lipids Lymphoma Endocrinology chemistry biology.protein lipids (amino acids peptides and proteins) Differential diagnosis business Lipoprotein |
| Zdroj: | Journal of Internal Medicine. 233:201-204 |
| ISSN: | 1365-2796 0954-6820 |
| DOI: | 10.1111/j.1365-2796.1993.tb00674.x |
| Popis: | Lipoprotein abnormalities seen in patients with inflammatory diseases are thought to develop secondary to circulating cytokines and the accompanying acute-phase response. Patient's with lymphoma may develop similar lipoprotein abnormalities but the mechanism is unclear. We report a patient with B-cell lymphoma who presented with an HDL cholesterol level of 3 mg dl-1, an ApoA level of 17.4 mg dl-1, elevated triglyceride level (272 mg dl-1) and an elevated ApoB level of 156 mg dl-1. Density gradient analysis of the patient's lipoproteins demonstrated a virtual absence of an identifiable HDL particle. Serum amyloid A and C-reactive protein were also elevated. All of the lipoprotein abnormalities resolved with chemotherapy and resolution of the acute-phase response. The acute-phase response may be associated with striking lipoprotein abnormalities in a subset of patients with lymphoma. Lymphoma should be included in the differential diagnosis of patients with hypertriglyceridaemia and low HDL cholesterol. |
| Databáze: | OpenAIRE |
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