Prevalence and risk factors for human immunodeficiency virus–associated neurocognitive impairment, 1996 to 2002: Results from an urban observational cohort
| Autor: | Andrea Antinori, Pasquale Narciso, Dora Larussa, Simonetta Galgani, Valerio Tozzi, Mauro Zaccarelli, Pietro Balestra, Angela Corpolongo, Rita Bellagamba, Giuseppe Ippolito, Patrizia Lorenzini, Pasquale Noto, Chrysoula Vlassi, Marinella Giulianelli, Ubaldo Visco-Comandini |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty AIDS Dementia Complex Hepatitis C virus Comorbidity medicine.disease_cause Serology Cohort Studies Cellular and Molecular Neuroscience Acquired immunodeficiency syndrome (AIDS) Risk Factors Virology Immunopathology Internal medicine Prevalence medicine Humans Risk factor Sida biology business.industry Age Factors biology.organism_classification medicine.disease Health Surveys Hepatitis C CD4 Lymphocyte Count Italy Neurology Cohort Immunology Female Neurology (clinical) Viral disease Nervous System Diseases Cognition Disorders business |
| Zdroj: | Journal of Neurovirology. 11:265-273 |
| ISSN: | 1538-2443 1355-0284 |
| Popis: | To assess prevalence and risk factors for human immunodeficiency virus (HIV)-related neurocognitive impairment (NCI), the authors performed a 7-year survey in the period 1996 to 2002. A total of 432 patients were examined. HIV-related NCI was diagnosed in 238 patients (55.1%), meeting the HIV dementia (HIV-D) criteria in 45 (10.4%). The prevalence of both NCI and HIV-D did not change significantly during the study period. Compared with patients without NCI, patients with NCI were older (40.4 versus 38.2 years; P = .003), had a higher prevalence of positive HCV serology (61.1% versus 38.9%; P = .003), and a lower nadir CD4 cell count (156 versus 222 cells/microl; P.001). Compared with patients seen during 1996 to 1999, patients with NCI seen during 2000 to 2002 were older (40.7 versus 38.8 years; P = .004), had a less advanced disease stage (previous acquired immunodeficiency syndrome [AIDS] 28.8% versus 65.7%; P.001) and a higher nadir CD4 count (174 versus 132 cells/microl; P = .026). This study showed an unchanged prevalence of both HIV-related NCI and HIV-D in the period 1996 to 2002. The authors found evidences for new additional potential risk factors for HIV-related NCI (older age, lower nadir CD4 count, positive hepatitis C virus [HCV] serology), and for a change of risk factors for NCI in the late highly active antiretroviral therapy (HAART) era (older age, less advanced disease, higher nadir CD4 count). |
| Databáze: | OpenAIRE |
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