Functional Measures of Grip Strength and Gait Remain Altered Long-Term in a Rat Model of Post-Traumatic Elbow Contracture
| Autor: | Ryan M. Castile, Paul Cannon, Emily H. Lakes, Kyle D. Allen, Aaron M. Chamberlain, Spencer P. Lake, Brittany Y. Jacobs, Alex J. Reiter, Griffin Kivitz |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
030222 orthopedics
medicine.medical_specialty business.industry Elbow Rat model Biomedical Engineering Research Papers Gait 03 medical and health sciences Grip strength 0302 clinical medicine Physical medicine and rehabilitation medicine.anatomical_structure Physiology (medical) Gait analysis medicine Joint Contracture Contracture medicine.symptom Forelimb business 030217 neurology & neurosurgery |
| Zdroj: | J Biomech Eng |
| ISSN: | 1528-8951 0148-0731 |
| Popis: | Post-traumatic joint contracture (PTJC) is a debilitating condition, particularly in the elbow. Previously, we established an animal model of elbow PTJC quantifying passive postmortem joint mechanics and histological changes temporally. These results showed persistent motion loss similar to what is experienced in humans. Functional assessment of PTJC in our model was not previously considered; however, these measures would provide a clinically relevant measure and would further validate our model by demonstrating persistently altered joint function. To this end, a custom bilateral grip strength device was developed, and a recently established open-source gait analysis system was used to quantify forelimb function in our unilateral injury model. In vivo joint function was shown to be altered long-term and never fully recover. Specifically, forelimb strength in the injured limbs showed persistent deficits at all time points; additionally, gait patterns remained imbalanced and asymmetric throughout the study (although a few gait parameters did return to near normal levels). A quantitative understanding of these longitudinal, functional disabilities further strengthens the clinical relevance of our rat PTJC model enabling assessment of the effectiveness of future interventions aimed at reducing or preventing PTJC. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|