Efficacy of MRI and mammography for breast-cancer screening in women with a familial or genetic predisposition
| Autor: | Louk V.A.M. Beex, H. M. Zonderland, Harry J. de Koning, Sybren L. Meijer, Peter E. Besnard, Theo Kok, Rob A. E. M. Tollenaar, Cecile T. M. Brekelmans, Radu A. Manoliu, Madeleine M.A. Tilanus-Linthorst, Jan C. Oosterwijk, Carla Boetes, Hans Peterse, Emiel J. Th. Rutgers, Jan G. M. Klijn, Inge Marie Obdeijn, Sara H. Muller, Mieke Kriege |
|---|---|
| Přispěvatelé: | Medical Oncology, Radiology & Nuclear Medicine, Surgery, Public Health, Other departments, Pathology, Damage and Repair in Cancer Development and Cancer Treatment (DARE), Targeted Gynaecologic Oncology (TARGON) |
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_treatment
Lobular carcinoma Breast cancer screening HISTORY Mass Screening Breast MRI Prospective Studies Prospective cohort study skin and connective tissue diseases Molecular diagnosis prognosis and monitoring [UMCN 1.2] medicine.diagnostic_test General Medicine Middle Aged Magnetic Resonance Imaging TRIALS OOPHORECTOMY Female Radiology Mastectomy Mammography Adult Risk medicine.medical_specialty Breast Neoplasms MUTATION CARRIERS Sensitivity and Specificity Breast cancer SDG 3 - Good Health and Well-being SURVEILLANCE MASTECTOMY medicine Humans Genetic Predisposition to Disease Germ-Line Mutation Mass screening Aged Gynecology Chi-Square Distribution BRCA2 MUTATION business.industry MORTALITY medicine.disease Survival Analysis HIGH-RISK ROC Curve Case-Control Studies DENSITY Functional Imaging [UMCN 1.1] business |
| Zdroj: | The New England Journal of Medicine, 351, 5, pp. 427-37 New England Journal of Medicine, 351(5), 427-437. Massachussetts Medical Society New England journal of medicine, 351(5), 427-437. Massachussetts Medical Society New England Journal of Medicine, 351(5), 427-437. MASSACHUSETTS MEDICAL SOC The New England Journal of Medicine, 351, 427-37 |
| ISSN: | 0028-4793 |
| Popis: | Contains fulltext : 58587.pdf (Publisher’s version ) (Open Access) BACKGROUND: The value of regular surveillance for breast cancer in women with a genetic or familial predisposition to breast cancer is currently unproven. We compared the efficacy of magnetic resonance imaging (MRI) with that of mammography for screening in this group of high-risk women. METHODS: Women who had a cumulative lifetime risk of breast cancer of 15 percent or more were screened every six months with a clinical breast examination and once a year by mammography and MRI, with independent readings. The characteristics of the cancers that were detected were compared with the characteristics of those in two different age-matched control groups. RESULTS: We screened 1909 eligible women, including 358 carriers of germ-line mutations. Within a median follow-up period of 2.9 years, 51 tumors (44 invasive cancers, 6 ductal carcinomas in situ, and 1 lymphoma) and 1 lobular carcinoma in situ were detected. The sensitivity of clinical breast examination, mammography, and MRI for detecting invasive breast cancer was 17.9 percent, 33.3 percent, and 79.5 percent, respectively, and the specificity was 98.1 percent, 95.0 percent, and 89.8 percent, respectively. The overall discriminating capacity of MRI was significantly better than that of mammography (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|