Retrospective assessment of radiation toxicity from a definitive‐intent, moderately hypofractionated image‐guided intensity‐modulated protocol for anal sac adenocarcinoma in dogs
| Autor: | Körner, Maximilian, Staudinger, Chris, Meier, Valeria Sabina, Rohrer Bley, Carla |
|---|---|
| Přispěvatelé: | University of Zurich, Körner, Maximilian |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
10253 Department of Small Animals Hypofractionated Radiation Therapy 040301 veterinary sciences 3400 General Veterinary medicine.medical_treatment 10192 Physics Institute Adenocarcinoma Anal sac adenocarcinoma 0403 veterinary science 03 medical and health sciences Dogs 0302 clinical medicine medicine Animals Dog Diseases Anal Sacs Stage (cooking) Radiation Injuries Retrospective Studies 630 Agriculture General Veterinary business.industry 04 agricultural and veterinary sciences medicine.disease Acute toxicity Intensity (physics) Radiation therapy 030220 oncology & carcinogenesis Toxicity 570 Life sciences biology Radiotherapy Intensity-Modulated Radiology business Progressive disease |
| Zdroj: | Veterinary and Comparative Oncology. 20:8-19 |
| ISSN: | 1476-5829 1476-5810 |
| DOI: | 10.1111/vco.12701 |
| Popis: | A recent calculation study predicted acceptable toxicity in pelvic organs at risk for a new definitive-intent, moderately hypofractionated radiation therapy (RT) protocol (12 x 3.8 Gy), when used with image-guided intensity-modulated radiation therapy (IG-IMRT). We hypothesized this protocol to result in clinically acceptable radiation toxicities. Dogs diagnosed with and irradiated for anal sac adenocarcinoma (ASAC) were retrospectively assessed. Eleven dogs were included, six had prior surgery. Before any therapy, staging according to Polton et al. resulted in the following distribution: stage 1 (n = 1), stage 2 (n = 1), stage 3a (n = 6), stage 3b (n = 3). We scored radiation toxicities at the end of therapy, at weeks 1, 3 and every 3 months after RT according to Veterinary Radiation Therapy Oncology Group radiation toxicity criteria. Clinical follow-up was maintained on regular intervals combined with computed tomography (n = 3). Median follow-up time for dogs still alive was 594 days (range: 224-972 days). Within 1 week post treatment, eight dogs (73%) developed grade 2 and four dogs (36%) grade 1 acute toxicity in the perianal region. All acute toxicities resolved or improved to grade 1 within 3 weeks after treatment. Late toxicity, for example, chronic colitis/diarrhoea, ulcerations, strictures or myelopathies was not observed in any patient. Five dogs were euthanized 105, 196, 401, 508 and 908 days after RT and six dogs were still alive, one in spite of progressive disease. The median progression-free survival was 908 days (95%CI: 215; 1602). The previous theoretically described definitive-intent, moderately hypofractionated protocol using IG-IMRT for the treatment of advanced ASAC showed clinically acceptable acute and late toxicities. |
| Databáze: | OpenAIRE |
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