Humoral and cellular immune response to Buerger's disease
| Autor: | Fatemeh Sadeghipour Kermani, Seyed Morteza Ehteshamfar, Jalil Tavakkol Afshari, Gholam Hosein Kazemzadeh, Mahmoud Mahmoudi, Mohammad-Hadi Saeed Modaghegh |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Erythrocytes Occlusive disease Blood Sedimentation 030204 cardiovascular system & hematology Severity of Illness Index 03 medical and health sciences 0302 clinical medicine Immune system Nephelometry and Turbidimetry Predictive Value of Tests Medicine Humans Radiology Nuclear Medicine and imaging Registries Buerger's disease Immunity Cellular biology business.industry Thromboangiitis Obliterans Complement C4 General Medicine Middle Aged medicine.disease Immunity Humoral Up-Regulation Immunology biology.protein Surgery Antibody Cardiology and Cardiovascular Medicine business 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Vascular. 28(4) |
| ISSN: | 1708-539X |
| Popis: | ObjectiveThromboangiitis obliterans is a nonatherosclerotic occlusive disease, affecting small to moderate sized arteries of the upper and lower extremities, leading to progressive inflammation and clot formation. However, the role of humoral and cell-mediated immunity in the development of this disease has not been clearly identified. The present study was intended to investigate the humoral and cellular immune response in patients with Buerger’s disease with different disease severity.MethodsIn an observational study, 80 male patients with Buerger’s disease were included and categorized into three groups (mild, moderate, and severe) based on clinical manifestations. After blood sampling, cellular phenotypes were determined, and erythrocyte sedimentation rate, immunoglobulins (Ig) A, M, G, and E, as well as C3 and C4 components of the complement system and complement hemolytic activity (CH50) were measured.ResultsThe mean age of the patient was 42.85 ± 8.39 years. Pulse abnormality, cold intolerance, and claudication were the most common symptoms. Eleven (13.75%), 46 (57.50%), and 23 (28.75%) patients had mild, moderate, and severe symptoms. Regression analyses showed that the presence of severe symptoms was significantly associated with elevated erythrocyte sedimentation rate and C4 levels ( p ConclusionBuerger’s disease in severe cases was associated with increased erythrocyte sedimentation rate and abnormal C4 levels. The alterations in these inflammatory biomarkers might be due to a secondary inflammatory response to the presence of ulcer or gangrene and the inflammatory process in patients with severe symptoms. |
| Databáze: | OpenAIRE |
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