The influence of product instability on slow-binding inhibition

Autor:	Manuela García-Moreno, J. M. Yago, F. García-Cánovas, Ramón Varón, Bent H. Havsteen, C. Garrido-Del Solo
Rok vydání:	2005
Předmět:	Pharmacology Chemistry Stereochemistry Thermodynamics General Medicine Slow binding Models Theoretical Kinetic energy Instability Decomposition Enzymes Substrate Specificity Enzyme inhibition Scientific method Product (mathematics) Drug Discovery Enzyme kinetics Enzyme Inhibitors Mathematical Computing
Zdroj:	Journal of Enzyme Inhibition and Medicinal Chemistry. 20:309-316
ISSN:	1475-6374 1475-6366
DOI:	10.1080/14756360500096651
Popis:	We present a kinetic study of an enzyme reaction that takes place with slow-binding inhibition where the immediate product undergoes a spontaneous or induced process of decomposition. A kinetic study of an enzyme process, in which a slow-binding inhibition process and a decomposition of the immediate product of the reaction take place simultaneously is performed. The corresponding explicit concentration-time equations were obtained. Using the analytical solutions obtained, which were tested numerically, we suggest a procedure that allows the discrimination between the particular cases considered and the evaluation of the principal kinetic parameters of the reaction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a26a9faa1b68217f1c9e76c3ea904fb0 https://doi.org/10.1080/14756360500096651 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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