Psychotic late-life depression less likely to relapse after electroconvulsive therapy
| Autor: | Kristof Vansteelandt, Filip Bouckaert, Pascal Sienaert, Mardien L. Oudega, Esmée Verwijk, Annemieke Dols, Eric van Exel, Jasmien Obbels, Margot J. Wagenmakers, Didi Rhebergen, Max L. Stek, Harm Pieter Spaans |
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| Přispěvatelé: | Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Mental Health, Psychiatry, Neurology, APH - Aging & Later Life, Brein en Cognitie (Psychologie, FMG), Medical Psychology, ANS - Mood, Anxiety, Psychosis, Stress & Sleep |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Depression scale medicine.medical_treatment Psychotic depression Lower risk Logistic regression behavioral disciplines and activities 03 medical and health sciences 0302 clinical medicine Electroconvulsive therapy Recurrence Internal medicine mental disorders medicine Humans Severe late-life depression In patient Prospective Studies Relapse Aged Depression business.industry Depression severity Late life depression medicine.disease 030227 psychiatry Psychiatry and Mental health Clinical Psychology Treatment Outcome Mood disorders business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Affective Disorders, 276, 984-990. Elsevier Wagenmakers, M J, Oudega, M L, Vansteelandt, K, Spaans, H P, Verwijk, E, Obbels, J, Rhebergen, D, van Exel, E, Bouckaert, F, Stek, M L, Sienaert, P & Dols, A 2020, ' Psychotic late-life depression less likely to relapse after electroconvulsive therapy ', Journal of Affective Disorders, vol. 276, pp. 984-990 . https://doi.org/10.1016/j.jad.2020.07.039 Journal of affective disorders, 276, 984-990. Elsevier |
| ISSN: | 0165-0327 |
| DOI: | 10.1016/j.jad.2020.07.039 |
| Popis: | BACKGROUND: A substantial number of patients with late-life depression (LLD) that remitted after ECT experience relapse. Identifying risk factors for relapse may guide clinical management to devote attention to those at increased risk. Therefore the current study aims to evaluate which baseline clinical characteristics are related to relapse within six months after successful ECT in patients with severe LLD.METHODS: 110 patients with LLD from the prospective naturalistic follow-up Mood Disorders in Elderly treated with Electro-Convulsive Therapy (MODECT) study were included. A total of 73 patients (66.4%) remitted after ECT, six patients had missing information on relapse, rendering to a total sample size of 67 patients. Relapse within six months after ECT was defined as a Montgomery Åsberg Depression Scale (MADRS)-score > 15, readmission or restart of ECT. Logistic regression analyses were conducted to examine the association between baseline clinical characteristics and relapse.RESULTS: A total of 22 patients (32.8%) experienced a relapse. Patients with psychotic depression were less likely to relapse (odds ratio = 0.32, p = .047), corrected for prior admissions; 76.9% of patients with psychotic depression remained remitted.LIMITATIONS: Due to its naturalistic design, no firm conclusions can be drawn on the effect of post-ECT treatment.CONCLUSIONS: Patients with psychotic depression had a lower risk to experience relapse after successful ECT. This result strengthens the hypothesis that psychotic depression might be a specific depression subtype with a favorable ECT outcome up to six months after ECT. |
| Databáze: | OpenAIRE |
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