Characterization of the immune profile of oral tongue squamous cell carcinomas with advancing disease

Autor: Nicholas C. Wong, Benjamin Solomon, Max Bulsara, Peter L. Friedland, James Lim, Michaela Lucas, Bob Mirzai, Katie Meehan, Yasir Khan, Chady Sader, Gisela Mir Arnau, Connull Leslie, Angela Jacques, Annette M. Lim, Timothy Semple
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Oncology
Male
Cancer Research
Lung Neoplasms
medicine.medical_treatment
Programmed Cell Death 1 Receptor
Gene Expression
Pembrolizumab
medicine.disease_cause
B7-H1 Antigen
0302 clinical medicine
Melanoma
Original Research
Cancer Biology
Immune signature
biology
FOXP3
Forkhead Transcription Factors
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Prognosis
Tongue Neoplasms
030220 oncology & carcinogenesis
CD4 Antigens
Female
medicine.medical_specialty
CD8 Antigens
lcsh:RC254-282
03 medical and health sciences
Tongue
Internal medicine
PD-L1
medicine
Humans
Radiology
Nuclear Medicine and imaging
Aged
Retrospective Studies
business.industry
Squamous Cell Carcinoma of Head and Neck
Gene Expression Profiling
Immunotherapy
Immune dysregulation
Gene signature
medicine.disease
Gene expression profiling
030104 developmental biology
oral tongue squamous cell carcinoma
PD‐L1
biology.protein
Lymph Nodes
business
Zdroj: Cancer Medicine
Cancer Medicine, Vol 9, Iss 13, Pp 4791-4807 (2020)
ISSN: 2045-7634
Popis: We investigated whether a unique immune response was instigated with the development of oral tongue squamous cell carcinomas (OTSCC), with/without nodal involvement, with/without recurrent metastatic disease, or within tumor involved nodes. One hundred and ten formalin‐fixed paraffin‐embedded samples were collected from a retrospective cohort of 67 OTSCC patients and 10 non‐cancerous tongue samples. Targets including CD4, CD8, FOXP3, PD‐L1, and PD‐1 were analyzed by immunohistochemistry. The Nanostring PanCancer Immune Profiling Panel was used for gene expression profiling. Data were externally validated in the The Cancer Genome Atlas (TCGA) head and neck (HNSCC), melanoma and lung squamous cell carcinoma (LSCC) cohorts. A 24‐immune gene signature was identified that discriminated more aggressive OTSCC cases, and although not prognostic in HNSCC was associated with survival in other TCGA cohorts (improved survival for melanoma, P
Oral tongue squamous cell carcinomas (OTSCC) exhibit primary immune failure to control carcinogenesis demonstrated by the absence of an immune response to the development of nodal metastases or recurrent disease. Proinflammatory immune gene expression is counteracted by immunosuppressive signaling mediated by FOXP3 and PD‐L1 expression. A gene signature was identified that was not prognostic in HNSCC but was significantly associated with survival in other cancers, demonstrating histotype‐dependent prognostic effects of immune regulation.
Databáze: OpenAIRE
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