Phéochromocytome et paragangliome
| Autor: | Nelly Burnichon, Erika Cornu, Michel Azizi, Ines Belmihoub, E. Billaud, Anne-Paule Gimenez-Roqueplo, Stéphanie Baron, F. Zinzindohoué, Laurence Amar, C. Grataloup |
|---|---|
| Přispěvatelé: | CCSD, Accord Elsevier, Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Paranglioma [SDV]Life Sciences [q-bio] 030209 endocrinology & metabolism Context (language use) Neuroendocrine tumors 03 medical and health sciences 0302 clinical medicine Genetic Paraganglioma Nuclear medicine imaging Internal Medicine Medicine Adrenal Genetic testing medicine.diagnostic_test business.industry Gastroenterology Metanephrines Phaeochromocytoma medicine.disease 3. Good health [SDV] Life Sciences [q-bio] medicine.anatomical_structure 030220 oncology & carcinogenesis Hypertension Surgical excision Radiology business Adrenal medulla |
| Zdroj: | La Revue de Médecine Interne La Revue de Médecine Interne, Elsevier, 2019, 40, pp.733-741. ⟨10.1016/j.revmed.2019.07.008⟩ La Revue De Médecine Interne La Revue De Médecine Interne, Elsevier, 2019, 40, pp.733-741. ⟨10.1016/j.revmed.2019.07.008⟩ |
| ISSN: | 0248-8663 1768-3122 |
| Popis: | International audience; Phaeochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumors that arise from the adrenal medulla or sympathetic and parasympathetic ganglia. These tumors produce most often catecholamines in excess, causing hypertension and sometimes severe acute cardiovascular complications. The diagnosis is based on plasma or urines metanephrines measurements and on conventional and nuclear medicine imaging. Catecholamines-producing PPGL is very unlikely if levels are normal. The diagnosis of PPGL cannot be made without visualization of a tumor. Therapeutic management consists mostly of surgical excision, after drug preparation, and should be done in referral centers. About 40% of pheochromocytomas and paragangliomas occur in the context of an autosomal inherited syndrome, making genetic testing essential. The follow-up must be prolonged because a metastatic evolution or a recurrence can be observed in about 15% of the cases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect