Differential effects of early-life nutrient restriction in long-lived GHR-KO and normal mice
| Autor: | Steve Verhulst, Andrzej Bartke, John J. Kopchick, Liou Y. Sun, Cristal M. Hill, Samuel McFadden, Joshua A. Huber, Justin Darcy, Yimin Fang, Richard A. Miller |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Litter (animal) medicine.medical_specialty Aging Somatotropic cell media_common.quotation_subject Adipose Tissue White Calorie restriction Longevity Growth hormone receptor White adipose tissue Biology 03 medical and health sciences Mice 0302 clinical medicine Internal medicine medicine Glucose homeostasis Animals Body Size Homeostasis media_common Caloric Restriction Mice Knockout Intracellular Signaling Peptides and Proteins Lipid metabolism Lipid Metabolism Insulin-Like Growth Factor Binding Protein 1 030104 developmental biology Endocrinology Food Growth Hormone Original Article Geriatrics and Gerontology 030217 neurology & neurosurgery |
| Zdroj: | GeroScience. 39(3) |
| ISSN: | 2509-2723 |
| Popis: | There is increasing evidence that growth hormone (GH) and insulin-like growth factor 1 (IGF-1) signaling (collectively referred to as somatotropic signaling) during development has a profound influence on aging and longevity. Moreover, the absence of GH action was shown to modify responses of adult mice to calorie restriction (CR) and other antiaging interventions. It was therefore of interest to determine whether GH resistance in GH receptor knockout (GHR-KO) mice would modify the effects of mild pre-weaning CR imposed by increasing the number of pups in a litter (the so-called litter crowding). In addition to the expected impact on body weight, litter crowding affected glucose homeostasis, hepatic expression of IGF-1 and genes related to lipid metabolism, and expression of inflammatory markers in white adipose tissue, with some of these effects persisting until the age of 2 years. Litter crowding failed to further extend the remarkable longevity of GHR-KO mice and, instead, reduced late life survival of GHR-KO females, an effect opposite to the changes detected in normal animals. We conclude that the absence of GH actions alters the responses to pre-weaning CR and prevents this intervention from extending longevity. |
| Databáze: | OpenAIRE |
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