Vaccine Design Based on Live Attenuated Cells of Toxoplasma gondii: A Review
| Autor: | Javad Koshki, Kobra Moradpour, Javad Akhtari, Kourosh Cheraghipour, Omid Mardanshah, Nader Pestechian, Mohammad Ali Mohaghegh, Abdolrazagh Marzban |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Bradyzoite Population Toxoplasma gondii 03 medical and health sciences 0302 clinical medicine Immune system Immunity vaccine medicine education lcsh:R5-920 education.field_of_study Attenuated vaccine Tachyzoite biology business.industry Chorioretinitis General Medicine medicine.disease biology.organism_classification Virology Toxoplasmosis 030104 developmental biology lcsh:Medicine (General) business 030217 neurology & neurosurgery Encephalitis |
| Zdroj: | Research in Molecular Medicine, Vol 5, Iss 4, Pp 1-11 (2017) |
| ISSN: | 2322-133X |
| Popis: | Toxoplasma gondii (T. gondii) is a well-known, commonly found pathogen by high proliferative activity in nucleated cells. This parasite has infected nearly one-third of the world’s population. Infection can result in chorioretinitis in immunocompetent hosts, encephalitis in HIV/AIDS positive patients and spontaneous abortion or neonatal death in fetuses infected with congenital toxoplasmosis. Development of vaccines for toxoplasmosis is of major importance for reducing routes of disease transmission among various host species in the world. Live attenuated vaccines resemble natural infectious agents very closely. Therefore, these vaccines are good enhancers of the immune system, often imparting lifelong immunity with only one or two doses. In this study, we review the current status of live attenuated vaccine development for Toxoplasma infection. |
| Databáze: | OpenAIRE |
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