Validation of the Semiquantitative Static SUVR Method for F-18-AV45 PET by Pharmacokinetic Modeling with an Arterial Input Function
| Autor: | Tobi Van den Bossche, Steven Deleye, Sigrid Stroobants, Steven Staelens, Sara Van Mossevelde, Sebastiaan Engelborghs, Hanne Struyfs, Julie Ottoy, Jeroen Verhaeghe, Charisse Somers, Sarah Ceyssens, Femke Soetewey, Jan Versijpt, Ellen Elisa De Roeck, Ellis Niemantsverdriet, Leonie Wyffels |
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| Přispěvatelé: | Faculty of Psychology and Educational Sciences, Neuroprotection & Neuromodulation, Clinical sciences, Neurology, Faculty of Arts and Philosophy |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Ethylene Glycols/metabolism Amyloid Kinetic modeling F-AV45 Precuneus Brain/blood supply Models Biological 030218 nuclear medicine & medical imaging White matter 03 medical and health sciences 0302 clinical medicine Cerebral perfusion Centrum semiovale medicine Humans Radiology Nuclear Medicine and imaging Cerebral perfusion pressure Biology Aged Volume of distribution Computer. Automation business.industry Biological Transport Blood flow Alzheimer's disease Aniline Compounds/metabolism medicine.anatomical_structure Cerebral blood flow Radiology Nuclear Medicine and imaging Posterior cingulate Cerebrovascular Circulation Positron-Emission Tomography Female Human medicine Nuclear medicine business 030217 neurology & neurosurgery |
| Zdroj: | The Journal of nuclear medicine |
| ISSN: | 0161-5505 |
| Popis: | Increased brain uptake of [18F]-AV45 visualized by PET is a key biomarker for Alzheimers disease (AD). The standardized uptake value ratio (SUVR) is widely used for quantification, but is subject to variability based on choice of reference region and changes in cerebral blood flow. Here we validate the SUVR method against the gold standard volume of distribution (VT) to assess cross-sectional differences in plaque load. Methods: Dynamic 60-min [18F]-AV45 (291 ± 67 MBq) and 1-min [15O]-H2O (370 MBq) scans were obtained in 35 age-matched elderly subjects, including 10 probable AD dementia, 15 amnestic mild cognitive impairment (aMCI) and 10 cognitively healthy controls (HC). [18F]-AV45 VT was determined from two-tissue compartment modeling using a metabolite-corrected plasma input function. Static SUVR was calculated at 50-60 min p.i., using either cerebellar gray matter (SUVRCB) or whole subcortical white matter (SUVRWM) as reference. Additionally, whole cerebellum, pons, centrum semiovale and a composite region were examined as alternative references. Blood flow was quantified by [15O]-H2O SUV. Data are presented as mean ± standard error of the mean (SEM). Results: There was rapid metabolization of [18F]-AV45 with only 35% of unchanged parent remaining at 10 minutes. Compared to VT, differences in cortical Aβ-load between aMCI and AD were overestimated by SUVRWM (+4 ± 2%) and underestimated by SUVRCB (-10 ± 2%). VT correlated better with SUVRWM (Pearsons r: from 0.63 for posterior cingulate to 0.89 for precuneus, p < 0.0001) than with SUVRCB (Pearsons r: from 0.51 for temporal lobe (p = 0.002) to 0.82 for precuneus (p < 0.0001)) in all tested regions. Correlation results for the alternative references were in-between those for CB and WM. [15O]-H2O data showed that blood flow was decreased in AD compared to aMCI in cortical regions (-5 ± 1%) and in the reference regions (CB: -9 ± 8%, WM: -8 ± 8%). Conclusion: Increased brain uptake of [18F]-AV45 assessed by the simplified static SUVR protocol does not truly reflect Aβ load. However, SUVRWM is better correlated with VT and more closely reflects VT differences between aMCI and AD than SUVRCB. |
| Databáze: | OpenAIRE |
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