Identification of flurbiprofen and its photoproducts in methanol by gas chromatography-mass spectrometry
| Autor: | Fu An Chen, Yi Chun Yu, Hsin Tsung Ho, Pen Yuan Lin, Su Hui Chao, An Bang Wu |
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| Rok vydání: | 2007 |
| Předmět: |
Ketone
Spectrophotometry Infrared Decarboxylation Photochemistry Clinical Biochemistry Flurbiprofen Biochemistry High-performance liquid chromatography Gas Chromatography-Mass Spectrometry Analytical Chemistry chemistry.chemical_compound Drug Discovery medicine Molecular Biology Chromatography High Pressure Liquid Pharmacology chemistry.chemical_classification Chromatography Ethanol Chemistry Singlet oxygen Methanol Anti-Inflammatory Agents Non-Steroidal General Medicine Spectrophotometry Ultraviolet Gas chromatography–mass spectrometry medicine.drug |
| Zdroj: | Biomedical chromatography : BMC. 21(5) |
| ISSN: | 0269-3879 |
| Popis: | A sample of 10 mm flurbiprofen in methanol (or ethanol) was photoirradiated with sixteen 8 W low-pressure quartz mercury lamps irradiated at 306 nm in a Panchum PR-2000 photochemical reactor. In total, four major photoproducts derived from each sample were observed from the HPLC chromatogram. The photoproducts were separated and their structures elucidated by various spectroscopic methods. Alternatively, using GC-MS, 11 major photoproducts were observed. A reaction scheme of flurbiprofen in methanol is proposed: the photochemical reaction routes occur mainly via esterification and decarboxylation, followed by oxidation with singlet oxygen to produce a ketone, alcohols and other derivatives. Copyright © 2007 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
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