The combination of ApoCIII, hepatic lipase and hormono sensitive lipase gene polymorphisms suggests an association with susceptibility to gestational hypertension
| Autor: | Yves Giguère, Jean-Claude Forest, Joël Girouard, Nathalie Bernard |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Gestational hypertension medicine.medical_specialty Hormone-sensitive lipase Biology Linkage Disequilibrium Apolipoproteins E Insulin resistance Pre-Eclampsia Pregnancy Risk Factors Internal medicine Cholesterylester transfer protein Genetics medicine Humans Genetic Predisposition to Disease Genetics (clinical) Apolipoprotein C-III Lipoprotein lipase Polymorphism Genetic Hypertension Pregnancy-Induced Lipase Sterol Esterase medicine.disease Endocrinology Case-Control Studies biology.protein Female Hepatic lipase Gene polymorphism Dyslipidemia |
| Zdroj: | Journal of Human Genetics. 52:244-254 |
| ISSN: | 1435-232X 1434-5161 |
| DOI: | 10.1007/s10038-006-0106-1 |
| Popis: | Dyslipidemia and insulin resistance contribute to the endothelial cell dysfunction in hypertensive disorders of pregnancy (HDP) and increase the long-term risk of cardiovascular disease (CVD). The genes linking susceptibility to gestational hypertension (GH) and/or preeclampsia (PE) to the long-term risk of CVD are still unknown. We evaluated the potential association between 14 polymorphisms from six genes involved in lipid metabolism and insulin action and the risk of HDP: namely the lipoprotein lipase (LPL), hepatic lipase (LIPC), hormone sensitive lipase (LIPE), cholesteryl ester transfer protein (CETP), ApoCIII and ApoE gene polymorphisms. Overall, 169 women with HDP [proteinuria (PE) and gestational hypertension without proteinuria (GH)] and 169 controls matched for age and year of delivery were genotyped. Homozygosity of the -514T allele of the -514C > T polymorphism (LIPC gene) decreased the risk of GH (OR = 0.17, CI(95): 0.02-0.76), while there were more -60G carriers of the -60C > G LIPE gene polymorphism (OR = 3.51, CI(95):1.02-12.10) among GH cases, but not in PE cases. The common ApoCIII two-locus -482CC/3238CC genotype was lower in women with GH compared with controls (OR = 0.53, CI(95): 0.3-0.9). The combined frequency of at-risk genotypes was higher in cases of GH compared with controls [one at-risk genotype: OR = 3.38 (95% CI: 0.48-41.8); two or more at-risk genotypes: OR = 7.14 (95% CI: 1.21-92.3, P = 0.01)], suggesting a gene-dose effect. We conclude that the combined effect of LIPC, LIPE and ApoCIII gene polymorphisms may increase the likelihood of GH, but seemingly not of PE. |
| Databáze: | OpenAIRE |
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