Multiple Micronutrients, Including Zinc, Selenium and Iron, are Positively Associated with Anemia in New Zealand Aged Care Residents

Autor: Jillian J. Haszard, Michelle J. Harper, Sue MacDonell, Lisa A Houghton, Jody C Miller, Rosalind S. Gibson, Malcolm R. Reid
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
0301 basic medicine
anti-secretory medications
Physiology
0302 clinical medicine
hemic and lymphatic diseases
Homes for the Aged
Micronutrients
030212 general & internal medicine
Aged
80 and over
Nutrition and Dietetics
biology
Iron deficiency
Micronutrient
anemia
Zinc
nursing home
Female
proton pump inhibitors
lcsh:Nutrition. Foods and food supply
Anemia
Iron
Nutritional Status
chemistry.chemical_element
lcsh:TX341-641
Article
total body iron
Selenium
03 medical and health sciences
Hepcidin
medicine
Humans
Geriatric Assessment
soluble transferrin receptor
Aged
Soluble transferrin receptor
030109 nutrition & dietetics
business.industry
interleukin-6
medicine.disease
Ferritin
Cross-Sectional Studies
chemistry
inflammation
biology.protein
Hemoglobin
business
Biomarkers
New Zealand
Food Science
Zdroj: Nutrients
Volume 13
Issue 4
Nutrients, Vol 13, Iss 1072, p 1072 (2021)
ISSN: 2072-6643
DOI: 10.3390/nu13041072
Popis: Anemia is a significant comorbidity for older adults not fully attributable to iron deficiency. Low-grade inflammation and other micronutrient deficiencies also contribute. This cross-sectional study examined the relationships between nutrient and non-nutrient factors with hemoglobin and anemia in 285 residents (>
65 years) of 16 New Zealand aged-care facilities. Blood samples were analyzed for hemoglobin, ferritin, sTfR, hepcidin, zinc, selenium, and interleukin-6 (IL-6), (with ferritin, sTfR, zinc and selenium adjusted for inflammation). Linear regression models examined the relationships between micronutrient biomarkers (iron, zinc, selenium, vitamin B-12 and D), age, sex, and health factors with hemoglobin. Thirty-two percent of participants exhibited anemia, although <
2% had either depleted iron stores or iron deficiency. Plasma zinc and selenium deficiencies were present in 72% and 38% of participants, respectively. Plasma zinc and total body iron (TBI) were positively associated (p <
0.05) with hemoglobin, while gastric acid suppressing medications, hepcidin, and interleukin-6 were inversely associated. These relationships were maintained after the application of anemia cut-offs. These findings emphasize the importance of considering multiple micronutrient deficiencies as risk factors for anemia.
Databáze: OpenAIRE
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