Cytochrome P450 2C9 gene polymorphism in phenytoin induced gingival enlargement: A case report
| Autor: | N S C Charles, S P K Kennedy Babu, Agila Samidorai, V. Ramesh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Phenytoin
lcsh:QD71-142 gene polymorphism lcsh:Analytical chemistry Cytochrome P450 gingival enlargement lcsh:RS1-441 Bioengineering Case Report Pharmacology Biology medicine.disease Cytochrome2C9 gene General Biochemistry Genetics and Molecular Biology Gingival enlargement lcsh:Pharmacy and materia medica medicine biology.protein Gene polymorphism General Pharmacology Toxicology and Pharmaceutics Adverse effect CYP2C9 Drug metabolism Pharmacogenetics medicine.drug |
| Zdroj: | Journal of Pharmacy and Bioallied Sciences, Vol 5, Iss 3, Pp 237-239 (2013) Journal of Pharmacy & Bioallied Sciences |
| ISSN: | 0976-4879 0975-7406 |
| Popis: | Gingival enlargement comprises any clinical condition in which an increase in the size of the gingiva is observed. Among the drugs that induce gingival enlargement, the antiepileptic agent phenytoin has been widely related to this condition. The Cytochrome P450(CYP) superfamily is the most commonly involved enzymes in metabolism of drugs. Common coding region CYP variants that affects drug elimination and response has been studied in great detail. Pharmacogenetic influences on drug metabolism have been widely reviewed and gene polymorphism of cytochrome P450 2C9 appeared to be responsible for much of the interindividual variability on drug elimination. Genetic variation in the CYP2C9 gene can affect metabolism, leading to altered phenotypes. Individuals with poor metaboliser alleles of CYP2C9 gene were shown to have a reduced metabolism of phenytoin compared with wild-type alleles. Thus identification of patients genotype prior to anti-epileptic drug administration could potentially prevent higher serum drug concentrations leading to adverse side effects such as gingival enlargement. This case report addresses the influence of CYP2C9 genetic polymorphism on Phenytoin drug metabolism thereby causing gingival enlargement. |
| Databáze: | OpenAIRE |
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