DaPeCa-7:comparative assessment of fluorodeoxyglucose positron emission tomography/computed tomography (CT) and conventional diagnostic CT in diagnosis of lymph node metastases, distant metastases and incidental findings in patients with invasive penile cancer
| Autor: | Tomas Frahm Nielsen, Jakob Kristian Jakobsen, Louise Alslev, Kirsten Bouchelouche, Elisabeth Albrecht‐Beste, Søren Svane Hoyer, Junia Costa, Pia Ipsen, Jørgen Bjerggaard Jensen, Birgitte Grønkær Toft, Kim Predbjørn Krarup |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
INVOLVEMENT #uroonc Time Factors ACCURACY 030232 urology & nephrology Computed tomography 030218 nuclear medicine & medical imaging 0302 clinical medicine Positron Emission Tomography Computed Tomography Clinical endpoint distant metastases #PenileCancer synchronous cancer Lymph node Incidental Findings medicine.diagnostic_test Middle Aged F-18-FDG PET/CT medicine.anatomical_structure Positron emission tomography Response Evaluation Criteria in Solid Tumors Lymphatic Metastasis Carcinoma Squamous Cell BIOPSY diagnostic accuracy Radiology SQUAMOUS-CELL CARCINOMA NEGATIVE PATIENTS lymph node metastases medicine.medical_specialty Urology Groin 03 medical and health sciences Fluorodeoxyglucose F18 medicine Penile cancer Humans In patient Neoplasm Invasiveness Penile Neoplasms METAANALYSIS Aged Neoplasm Staging business.industry computed tomography F-18-fluorodeoxyglucose positron emission tomography medicine.disease penile cancer Histopathology Lymph Nodes Radiopharmaceuticals business Tomography X-Ray Computed Follow-Up Studies |
| Zdroj: | Jakobsen, J K, Frahm Nielsen, T, Ipsen, P, Albrecht-Beste, E, Cardoso Costa, J, Alslev, L, Predbjørn Krarup, K, Grønkær Toft, B, Høyer, S, Bouchelouche, K & Bjerggaard Jensen, J 2021, ' DaPeCa-7 : comparative assessment of fluorodeoxyglucose positron emission tomography/computed tomography (CT) and conventional diagnostic CT in diagnosis of lymph node metastases, distant metastases and incidental findings in patients with invasive penile cancer ', BJU International, vol. 127, no. 2, pp. 254-262 . https://doi.org/10.1111/bju.15206 |
| Popis: | OBJECTIVES: To evaluate diagnostic accuracy of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) compared to contrast-enhanced CT in assessment of inguinal lymph node (ILN) metastases, distant metastases and synchronous cancers in patients with penile squamous cell carcinoma (pSCC).PATIENTS AND METHODS: During a 4-year period, patients with pSCC were scheduled for FDG PET/CT prior to surgical treatment at two referral centres that manage all penile cancers in Denmark. The primary endpoint was diagnostic accuracy of FDG PET/CT and of CT alone with histopathology or Response Evaluation Criteria In Solid Tumors (RECIST) as reference.RESULTS: We evaluated 171 patients for distant metastases and synchronous incident cancers and examined 286 groins in 143 patients for LN metastases by FDG PET/CT. Six groins disclosed false negatives. FDG PET/CT sensitivity was 85.4% per patient. In 135 patients (270 groins), CT images were evaluated separately and 22 groins disclosed false negatives. CT sensitivity was 47.5% per patient. FDG PET/CT detected pSCC distant metastases in seven patients. Distant metastases from other cancers were newly detected in three patients. In eight patients, an incidental synchronous cancer was detected. Seven out of the 18 distant malignancies detected depended on FDG PET information.CONCLUSION: This study underlines the increased diagnostic accuracy of FDG PET/CT compared to CT alone in the evaluation of ILN status. In patients with palpable LNs, the advantage of FDG PET/CT over CT is less pronounced. FDG PET/CT may play a role in penile cancer evaluation. |
| Databáze: | OpenAIRE |
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