Effects of glucagon, insulin and cyclic-AMP on mitochondrial calcium uptake in the liver
| Autor: | Ana Maria Andia-Waltenbaugh, P. Divakaran, Jeanie M. Wood, Naomi Kraus Friedmann, S. Kimura |
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| Rok vydání: | 1978 |
| Předmět: |
Male
medicine.medical_specialty Time Factors medicine.medical_treatment Mitochondria Liver In Vitro Techniques Mitochondrion Glucagon Oxidative Phosphorylation General Biochemistry Genetics and Molecular Biology In vivo Internal medicine Perfused liver Cyclic AMP medicine Animals Insulin Mitochondrial calcium uptake General Pharmacology Toxicology and Pharmaceutics Chemistry General Medicine Rats Endocrinology Calcium Hormone |
| Zdroj: | Life Sciences. 23:2437-2443 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(78)90303-x |
| Popis: | The effects of glucagon and insulin administration in vivo on hepatic mitochondrial Ca 2+ uptake were compared with the effects of these hormones when they were added directly to the perfused liver. Glucagon administration increased mitochondrial calcium uptake both in vivo and in the perfused liver. In contrast, while injection of insulin into rats stimulated, addition of insulin to the perfusate, inhibited Ca 2+ uptake. Cyclic AMP, when added to the perfusate, also increased the uptake of Ca 2+ by mitochondria, subsequently isolated. The possible implications of the results are discussed. |
| Databáze: | OpenAIRE |
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