Computer-aided identification of protein targets of four polyphenols in Alzheimer's disease (AD) and validation in a mouse AD model
| Autor: | Chaoyun Li, Zhi-Yuan Zhang, Hanli Wen, Hong Kang, Hermann J. Schluesener, Zhiwei Cao, Ping Meng, Ben-Zheng Zhang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Genetically modified mouse
cerebral amyloidosis 02 engineering and technology Biology Pharmacology 01 natural sciences Neuroprotection General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Hesperidin In vivo KEGG 010401 analytical chemistry food and beverages Calpain General Medicine Alzheimer's disease 021001 nanoscience & nanotechnology 0104 chemical sciences polyphenol behavioral deficit chemistry INVDOCK biology.protein Original Article 0210 nano-technology Baicalin Icariin |
| Zdroj: | Journal of Biomedical Research |
| ISSN: | 1674-8301 |
| DOI: | 10.7555/jbr.32.20180021 |
| Popis: | Natural polyphenols are a large class of phytochemicals with neuroprotective effects. Four polyphenolic compounds: hesperidin, icariin, dihydromyricetin and baicalin were selected to evaluate their effects on Alzheimer's disease (AD). We analyzed by an inverse docking procedure (INVDOCK) the potential protein targets of these polyphenols within the KEGG AD pathway. Consequently, their therapeutic effects were evaluated and compared in a transgenic APP/PS1 mouse model of AD. These polyphenols were docked to several targets, including APP, BACE, PSEN, IDE, CASP, calpain and TNF-α, suggesting potential in vivo activities. Five month old transgenic mice were treated with these polyphenols. Icariin and hesperidin restored behavioral deficits and ameliorated Aβ deposits in both the cortex and hippocampus while baicalin and dihydromyricetin showed no substantial effects. Our findings suggest that hesperidin and icariin could be considered potential therapeutic candidates of human AD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|