Choice of toothpaste for the elderly: an in vitro study
| Autor: | Karina Monteleone Lachowski, Maria Ângela Pita Sobral, Stella da Silva Ferreira, Márcia Martins Marques, Renata Duarte de Souza-Rodrigues, Roberta Souza D'Almeida-Couto |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Toothbrushing
Time Factors business.product_category Citotoxicidade Cell Survival Surface Properties Tetrazolium Salts Dentistry Context (language use) Sensodyne Pasta de dente Materials Testing Dentin Humans Medicine In vitro study General Materials Science MTT assay Viability assay Cells Cultured Aged Analysis of Variance Formazans Toothpaste Toxicity business.industry Fibroblasts lcsh:RK1-715 medicine.anatomical_structure Tooth wear Desgastes dos dentes lcsh:Dentistry Cuidados bucais Tooth Wear Dentina business Toothpastes |
| Zdroj: | Brazilian Oral Research, Vol 29, Iss 1, Pp 1-7 (2015) Repositório Institucional da UFPA Universidade Federal do Pará (UFPA) instacron:UFPA Brazilian Oral Research v.29 n.1 2015 Brazilian Oral Research Sociedade Brasileira de Pesquisa Odontológica (SBPqO) instacron:SBPQO Brazilian Oral Research, Volume: 29, Issue: 1, Pages: 1-7, Published: 10 JUL 2015 |
| ISSN: | 1807-3107 |
| Popis: | Hyposalivation and dental root exposure in the elderly are problems that require special oral care. In this context, the characteristics of certain toothpastes are of particular importance. Thus, the aim of this study was to evaluate the cytotoxicity and dentin wear caused by seven different toothpastes. For dentin wear analysis, 40 root dentin specimens were submitted to 20,000 brushing cycles with the different toothpastes and distilled water (control group-CG), using a brushing machine. Dentin surface loss (SL) was measured by contact profilometer. The cytotoxicity of each toothpaste was tested using cultured fibroblasts submitted to a cell-culture-conditioned medium. Fresh medium served as the control. Cell viability was assessed by MTT assay after 24 h of contact with the conditioned media. The data were analyzed statistically by ANOVA, followed by Tukey’s test (p < 0.05). The SL of the CG was minimal and significantly lower than that of the Oral B Pro Health (OBPH) group (p < 0.05). All other groups presented SL in between that of the CG and the Oral B Pro Health OBPH group, except for the Sensodyne (SEN) group, which presented SL similar to that of CG (p = 0.05). The SEN group presented a percentage of viable cells similar to that of CG: between 60-89%. All the other toothpastes showed high cytotoxicity, with cell viability less than 50% of the CG. Considering study limitations, we concluded that only one of the seven tested toothpastes exhibited the most desirable toothpaste characteristics for the worldwide growing elderly population (e.g. low cytotoxicity and low-abrasive potential). |
| Databáze: | OpenAIRE |
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