Lipoid proteinosis-new immunopathological observations
| Autor: | S. Rasbridge, A. Temple, Martin M. Black, Phillip H. McKee, J.A. Newton, F.M. Pope |
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| Rok vydání: | 1991 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty biology business.industry Alpha (ethology) Chromosome Dermatology Abnormal distribution Collagen metabolism biology.protein medicine Humans Lipoid Proteinosis of Urbach and Wiethe Collagen Antibody Skin pathology business Gene Direct fluorescent antibody Skin |
| Zdroj: | Clinical and Experimental Dermatology. 16:350-354 |
| ISSN: | 1365-2230 0307-6938 |
| DOI: | 10.1111/j.1365-2230.1991.tb00399.x |
| Popis: | Lipoid proteinosis is described in a family of Scottish descent. Chromosome studies performed on five members were normal. Direct immunofluorescence studies performed on skin with anti-collagen antibodies showed an abnormal distribution of collagen within the skin. No abnormality was detected in DNA extracted from lymphocytes taken from five family members, when probed with gene probes to collagen types alpha 1 (I), alpha 2 (I), alpha 1 (III) and alpha 2 (V). |
| Databáze: | OpenAIRE |
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