Hypothermia-treated neonates with hypoxic-ischemic encephalopathy: Optimal timing of quantitative ADC measurement to predict disease severity
| Autor: | Alex Penn, Yauk K Lee, Mahesh R. Patel, Dongli Song, Bo Yoon Ha, Rajul Pandit |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Encephalopathy Ischemia Severity of Illness Index Hypoxic Ischemic Encephalopathy 03 medical and health sciences 0302 clinical medicine Disease severity Hypothermia Induced Predictive Value of Tests 030225 pediatrics Internal medicine Image Processing Computer-Assisted medicine Humans Radiology Nuclear Medicine and imaging Retrospective Studies Brain Imaging Hypothermia treatment business.industry Infant Newborn Brain General Medicine Hypoxia (medical) Hypothermia Time optimal medicine.disease Diffusion Magnetic Resonance Imaging Treatment Outcome Hypoxia-Ischemia Brain Cardiology Female Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | The Neuroradiology Journal. 30:28-35 |
| ISSN: | 2385-1996 1971-4009 |
| DOI: | 10.1177/1971400916678229 |
| Popis: | To determine the optimal time window for MR imaging with quantitative ADC measurement in neonatal HIE after hypothermia treatment, a retrospective review was performed on consecutive hypothermia-treated term neonates with HIE, with an initial and follow-up MR imaging within the first two weeks of life. Three neuroradiologists categorized each set of MR imaging as normal, mild, moderate or severe HIE based on a consensus review of the serial imaging. The lowest ADC values from the white matter, corpus callosum, and basal ganglia/thalamus were measured. The ADC values between mild-moderate and severe HIE were compared using a Student’s t-test over a range of different time windows. A total of 33 MR imaging examinations were performed on 16 neonates that included three normal, four mild, five moderate, and four severe HIE. The time window of 3–10 days showed a statistically significant decrease in ADC value in severe HIE compared to mild-moderate HIE in all three locations, respectively: white matter 0.5 ± 0.22 versus 0.83 ± 0.27 ( p value 0.01), corpus callosum 0.69 ± 0.19 versus 0.91 ± 0.17 ( p value 0.01), and basal ganglia/thalamus 0.63 ± 0.16 versus 0.98 ± 0.06 ( p value |
| Databáze: | OpenAIRE |
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