Calixarene-decorated liposomes for intracellular cargo delivery
| Autor: | Jeffrey D. Esko, Alessandro Casnati, Ilaria Morbioli, Yitzhak Tor, Francesco Sansone |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Liposome
Chemistry Bilayer Organic Chemistry Cationic polymerization 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Biochemistry 0104 chemical sciences Liposomes Calixarene Amphiphile Biophysics Physical and Theoretical Chemistry 0210 nano-technology Intracellular |
| Zdroj: | Organic & Biomolecular Chemistry. 19:6598-6602 |
| ISSN: | 1477-0539 1477-0520 |
| DOI: | 10.1039/d1ob01055g |
| Popis: | Amphiphilic calix[4]arenes, functionalized with guanidinium groups, are used to decorate the outer surface of liposomes and significantly improve the cellular uptake of a cargo compared to plain liposomes. The improved uptake is elicited and mediated by the interaction between the cationic polar heads of the macrocycle units embedded in the liposome bilayer and anionic heparan-sulfate proteoglycans surrounding the exterior of cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|