In vivo imaging of functional disruption, recovery and alteration in rat olfactory circuitry after lesion
| Autor: | Jennifer A. Flexman, Thomas J. Morrow, Satoshi Minoshima, Kenneth R. Maravilla, Yoshimi Anzai, Donna J. Cross |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Olfactory system Pathology medicine.medical_specialty Cognitive Neuroscience Anterior commissure Functional Laterality Rats Sprague-Dawley Stereotaxic Techniques Lesion In vivo Image Processing Computer-Assisted medicine Animals Premovement neuronal activity Stroke Administration Intranasal Brain Mapping Manganese business.industry Olfactory Pathways Commissure medicine.disease Magnetic Resonance Imaging Rats Smell Neurology medicine.symptom business Neuroscience Preclinical imaging |
| Zdroj: | NeuroImage. 32:1265-1272 |
| ISSN: | 1053-8119 |
| DOI: | 10.1016/j.neuroimage.2006.04.229 |
| Popis: | Compensatory changes following disruption of neuronal circuitry have been indicated by previous imaging studies of stroke and other brain injury, but evidence of the pathways involved in such dynamic changes has not been shown in vivo. We imaged rats before and after lesion-induced disruption of the lateral olfactory tract to investigate the subsequent recovery and/or reorganization of functional neuronal circuitry. Serial magnetic resonance imaging was performed following intranasal administration of a paramagnetic track tracer Mn2+. Images were analyzed using statistical mapping techniques in the stereotactic coordinate system. At 1 week post-lesion, Mn2+ transport caudal to lesion was reduced as expected, and more importantly, increased transport through the anterior commissure was seen. At 4 weeks post-lesion, there was recovery of transport caudal to lesion, and increased transport through the anterior commissure extended to the contralateral olfactory cortex. Correlation analysis of regional Mn2+ transport indicated that contralateral enhancement was not simply due to septal window spillover. This study demonstrates for the first time in vivo evidence of compensatory changes in functional neuronal activity to a contralateral pathway through the commissure following brain injury. |
| Databáze: | OpenAIRE |
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