One size fits all? Direct evidence for the heterogeneity of genetic drift throughout the genome
| Autor: | Rasmus Froberg Brøndum, Belén Jiménez-Mena, Goutam Sahana, Paula Tataru, Bernt Guldbrandtsen, Thomas Bataillon |
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| Přispěvatelé: | Génétique Animale et Biologie Intégrative (GABI), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Bioinformatics Research Center (BiRC), Aarhus University [Aarhus], Department of Haematolog, Center for Quantitative Genetics and Genomics, Department of Molecular Biology and Genetics, Erasmus-Mundus PhD School 'EGS-ABG', INRA Animal Genetics, project 'Genomic selection-from function to efficient utilization in cattle breeding' [3405-10-0137], Aarhus University, Aalborg University Hospital |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Conservation genetics [SDV]Life Sciences [q-bio] Population Biology Polymorphism Single Nucleotide linked selection 03 medical and health sciences Effective population size Genetic drift Genetic variation Journal Article Holstein breed Animals Inbreeding Selection Genetic education Allele frequency Selection (genetic algorithm) 2. Zero hunger Genetics education.field_of_study Genome Genetic Drift Genetic Variation Agricultural and Biological Sciences (miscellaneous) 030104 developmental biology Genetics Population Evolutionary biology quantitative trait loci Cattle genetic drift General Agricultural and Biological Sciences effective population size Population Genetics |
| Zdroj: | Biology Letters Biology Letters, Royal Society, The, 2016, 12 (7), pp.1-4. ⟨10.1098/rsbl.2016.0426⟩ Jiménez-Mena, B, Tataru, P, Brøndum, R F, Sahana, G, Guldbrandtsen, B & Bataillon, T 2016, ' One size fits all? Direct evidence for the heterogeneity of genetic drift throughout the genome ', Biology Letters, vol. 12, no. 7, 20160426 . https://doi.org/10.1098/rsbl.2016.0426 Jimenez Mena, B, Tataru, P, Brøndum, R F, Sahana, G, Guldbrandtsen, B & Bataillon, T 2016, ' One size fits all? Direct evidence for the heterogeneity of genetic drift throughout the genome. ', Biology Letters, vol. 12, no. 7 . https://doi.org/10.1098/rsbl.2016.0426 |
| ISSN: | 1744-9561 |
| Popis: | Effective population size ( N e ) is a central parameter in population and conservation genetics. It measures the magnitude of genetic drift, rates of accumulation of inbreeding in a population, and it conditions the efficacy of selection. It is often assumed that a single N e can account for the evolution of genomes. However, recent work provides indirect evidence for heterogeneity in N e throughout the genome. We study this by examining genome-wide diversity in the Danish Holstein cattle breed. Using the differences in allele frequencies over a single generation, we directly estimated N e among autosomes and smaller windows within autosomes. We found statistically significant variation in N e at both scales. However, no correlation was found between the detected regional variability in N e , and proxies for the intensity of linked selection (local recombination rate, gene density), or the presence of either past strong selection or current artificial selection on traits of economic value. Our findings call for further caution regarding the wide applicability of the N e concept for understanding quantitatively processes such as genetic drift and accumulation of consanguinity in both natural and managed populations. |
| Databáze: | OpenAIRE |
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