The flavonoid monoHER promotes the adaption to oxidative stress during the onset of NAFLD
| Autor: | Kristien J.A. Lemmens, Marie-Jose Drittij, Bregje van de Wier, Wim J.F. van der Vijgh, Guido R.M.M. Haenen, Eleonore S. Köhler, Ger H. Koek, Aalt Bast |
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| Přispěvatelé: | Farmacologie en Toxicologie, Interne Geneeskunde, Anatomie & Embryologie, RS: NUTRIM - R3 - Chronic inflammatory disease and wasting, RS: NUTRIM - R2 - Gut-liver homeostasis, RS: CARIM - R3 - Vascular biology |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Antioxidant
GPX3 NF-E2-Related Factor 2 medicine.medical_treatment Biophysics Pharmacology Biology medicine.disease_cause Biochemistry Antioxidants Liver disease chemistry.chemical_compound Mice Non-alcoholic Fatty Liver Disease medicine Animals Molecular Biology Flavonoids Glutathione Peroxidase Fatty liver Wild type Membrane Proteins nutritional and metabolic diseases Cell Biology Glutathione medicine.disease Mice Inbred C57BL Hydroxyethylrutoside Oxidative Stress chemistry Gene Expression Regulation Receptors LDL LDL receptor Immunology Female Reactive Oxygen Species Oxidation-Reduction Oxidative stress Heme Oxygenase-1 |
| Zdroj: | Biochemical and Biophysical Research Communications, 456(1), 179-182. Elsevier |
| ISSN: | 1090-2104 0006-291X |
| Popis: | Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease. An evidence-based pharmacological treatment for NAFLD is still lacking, but flavonoids have shown therapeutic potential. The present study was designed to investigate the effect of the flavonoid monoHER on the onset of NAFLD in Ldlr(-/-) mice on a high-fat and high-cholesterol diet. The focus was put on the effect on oxidative stress as well as the adaptive response. Wild type mice served as a control and the effect of monoHER was compared to that of a placebo. In the Ldlr(-/-) group, monoHER provided only a mild protection against oxidative stress. In the placebo Ldlr(-/-) group an adaptive response elicited by the NRF2 antioxidant defense system was observed, evidenced by a higher HO-1 and Gpx3 gene expression, as well as an increased redox status, evidenced by the higher GSH/GSSG ratio. In the monoHER treated Ldlr(-/-) group both the adaptive response as well as the increase in redox status tended to be higher, although this did not reach significance on a group level. Unexpectedly, a strong within animal relationship was found that links a high adaptive response to a low redox status in the monoHER Ldlr(-/-) group. This correlation was absent in the placebo and wild type group. The concept that emerges is that a thiol-reactive oxidation product of monoHER, formed during oxidative stress, selectively induces the NRF2 pathway and enforces the endogenous antioxidant shield, to provide protection against NAFLD. |
| Databáze: | OpenAIRE |
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