Liraglutide administration improves hormonal/metabolic profile and reproductive features in women with HAIR-AN syndrome
| Autor: | N Angelopoulos, S Livadas, G Kassi, A Lytras, I Androulakis, F Papagiannopoulos |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Hirsutism
Endocrinology Diabetes and Metabolism Physiology Acanthosis nigricans White lcsh:Diseases of the endocrine glands. Clinical endocrinology Gynaecology 0302 clinical medicine PCOS Insulin Testosterone HAIR-AN syndrome GLP1 agonists hirsutism Greece Polycystic ovary Ovaries 030220 oncology & carcinogenesis Androgens Female medicine.drug Anovulation Adult 030209 endocrinology & metabolism Gynaecological endocrinology 03 medical and health sciences Insulin resistance Hyperinsulinaemia Internal Medicine medicine HOMA Glucose tolerance (oral) June lcsh:RC648-665 Liraglutide business.industry Hyperandrogenism Androstenedione medicine.disease Novel Treatment Acne Amenorrhoea business |
| Zdroj: | Endocrinology, Diabetes & Metabolism Case Reports, Vol 1, Iss 1, Pp 1-4 (2020) Endocrinology, Diabetes & Metabolism Case Reports |
| ISSN: | 2052-0573 |
| Popis: | Summary HAIR-AN syndrome, the coexistence of Hirsutism, Insulin Resistance (IR) and Acanthosis Nigricans, constitutes a rare nosologic entity. It is characterized from clinical and biochemical hyperandrogenism accompanied with severe insulin resistance, chronic anovulation and metabolic abnormalities. Literally, HAIR-AN represents an extreme case of polycystic ovary syndrome (PCOS). In everyday practice, the management of HAIR-AN constitutes a therapeutic challenge with the available pharmaceutical agents. Specifically, the degree of IR cannot be significantly ameliorated with metformin administration, whereas oral contraceptives chronic administration is associated with worsening of metabolic profile. Liraglutide and exenatide, in combination with metformin, have been introduced in the management of significantly obese women with PCOS with satisfactory results. Based on this notion, we prescribed liraglutide in five women with HAIR-AN. In all participants a significant improvement regarding the degree of IR, fat depositions, androgen levels and the pattern of menstrual cycle was observed, with minimal weight loss. Furthermore, one woman became pregnant during liraglutide treatment giving birth to a healthy child. Accordingly, we conclude that liraglutide constitutes an effective alternative in the management of women with HAIR-AN. Learning points: HAIR-AN management is challenging and classic therapeutic regimens are ineffective. Literally HAIR-AN syndrome, the coexistence of Hirsutism, Insulin Resistance and Acanthosis Nigricans, represents an extreme case of polycystic ovary syndrome. In cases of HAIR-AN, liraglutide constitutes an effective and safe choice. |
| Databáze: | OpenAIRE |
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