A look inside the diabetic brain: Contributors to diabetes-induced brain aging
| Autor: | Shayna A. Wrighten, Lawrence P. Reagan, Claudia A. Grillo, Gerardo G. Piroli |
|---|---|
| Přispěvatelé: | Department of Pharmacology, University of South Carolina [Columbia] |
| Rok vydání: | 2009 |
| Předmět: |
Aging
medicine.medical_specialty medicine.medical_treatment Central nervous system Hippocampus tau Proteins Article 03 medical and health sciences Cognition 0302 clinical medicine Diabetes mellitus Internal medicine Cognitive Changes medicine Animals Humans Insulin Dementia Obesity skin and connective tissue diseases Molecular Biology Brain aging ComputingMilieux_MISCELLANEOUS 030304 developmental biology 0303 health sciences business.industry Life Sciences Brain Neurodegenerative Diseases Alzheimer's disease medicine.disease 3. Good health Diabetes Mellitus Type 1 Glucose medicine.anatomical_structure Endocrinology Diabetes Mellitus Type 2 Molecular Medicine sense organs Cognition Disorders business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Biochimica et Biophysica Acta-Molecular Basis of Disease Biochimica et Biophysica Acta-Molecular Basis of Disease, Elsevier, 2009, 1792 (5), pp.444. ⟨10.1016/j.bbadis.2008.10.013⟩ |
| ISSN: | 0925-4439 |
| Popis: | Central nervous system (CNS) complications resulting from diabetes is a problem that is gaining more acceptance and attention. Recent evidence suggests morphological, electrophysiological and cognitive changes, often observed in the hippocampus, in diabetic individuals. Many of the CNS changes observed in diabetic patients and animal models of diabetes are reminiscent of the changes seen in normal aging. The central commonalities between diabetes-induced and age-related CNS changes have led to the theory of advanced brain aging in diabetic patients. This review summarizes the findings of the literature as they relate to the relationship between diabetes and dementia and discusses some of the potential contributors to diabetes-induced CNS impairments. |
| Databáze: | OpenAIRE |
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