Discovery of Highly Potent and Selective Matrix Metalloproteinase-7 Inhibitors by Hybridizing the S1' Subsite Binder with Short Peptides

Autor:	Hideaki Tabuse, Kumi Abe-Sato, Harumi Kanazawa, Miyoko Yashiro, Yunoshin Tamura, Masafumi Kamitani, Kosuke Hitaka, Emi Gunji, Akiko Mitani, Naoki Kojima, Yusuke Oka
Rok vydání:	2022
Předmět:	Matrix Metalloproteinase 7 Drug Discovery Molecular Medicine Humans Matrix Metalloproteinase 2 Matrix Metalloproteinase Inhibitors Peptides
Zdroj:	Journal of medicinal chemistry. 65(19)
ISSN:	1520-4804
Popis:	Matrix metalloproteinase-7 (MMP-7) has emerged as a protein playing important roles in both physiological and pathophysiological processes. Despite the growing interest in MMP-7 as a potential therapeutic target for diseases including cancer and fibrosis, potent and selective MMP-7 inhibitors have yet to be identified. Compound
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2475dd8ba597803edce752b11c7feb1 https://pubmed.ncbi.nlm.nih.gov/36137271 Zobrazit plný text záznamu