Structure and ovarian expression of the oxytocin gene in sheep
| Autor: | D Nollmeyer, Richard Ivell, Nicholas Hunt, J A McCracken, J C Lamsa, Nicole Abend, B Brackman |
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| Rok vydání: | 1990 |
| Předmět: |
endocrine system
medicine.medical_specialty Molecular Sequence Data Restriction Mapping Luteal phase Biology Oxytocin Endocrinology Internal medicine Lactation Gene expression Genetics medicine Animals Amino Acid Sequence RNA Messenger Promoter Regions Genetic Molecular Biology Gene Regulation of gene expression Electrophoresis Agar Gel Sheep Base Sequence Ovary Nucleic Acid Hybridization Blotting Northern Oxytocin receptor medicine.anatomical_structure Reproductive Medicine Gene Expression Regulation Animal Science and Zoology Female Corpus luteum hormones hormone substitutes and hormone antagonists Developmental Biology Biotechnology medicine.drug |
| Zdroj: | Reproduction, fertility, and development. 2(6) |
| ISSN: | 1031-3613 |
| Popis: | In sheep, the oxytocin gene is highly up-regulated in the ovarian corpus luteum as well as in the hypothalamus. This expression is already elevated on Day 2 of the oestrous cycle, representing 1% of all transcripts in this tissue, and it declines thereafter to low levels after Day 6 of the cycle. In order to study the mechanisms involved in luteal oxytocin gene expression, we have cloned and sequenced the oxytocin gene from the sheep. This gene is closely homologous to other known mammalian oxytocin genes, especially the bovine one, and comparison of the gene promoter regions highlights several blocks of putative control elements. |
| Databáze: | OpenAIRE |
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