Clinical Outcomes of Intravitreal Preservative-Free Triamcinolone Preparation (Triesence®) for Cystoid Macular Oedema and Inflammation in Patients with Uveitis
| Autor: | Jiten Moraji, Laura R Steeples, Nicholas P Jones, Nitin Anand |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Triamcinolone acetonide Adolescent Visual Acuity Inflammation Triamcinolone Acetonide Macular Edema Retina Uveitis 03 medical and health sciences 0302 clinical medicine Triamcinolone preparation Ophthalmology medicine Immunology and Allergy Humans In patient Preservative free Glucocorticoids Intraocular Pressure Aged Retrospective Studies Aged 80 and over business.industry Preservatives Pharmaceutical Retrospective cohort study Middle Aged medicine.disease humanities Treatment Outcome Cystoid macular oedema Intravitreal Injections Retreatment 030221 ophthalmology & optometry Female medicine.symptom business 030217 neurology & neurosurgery Tomography Optical Coherence medicine.drug |
| Zdroj: | Ocular immunology and inflammation. 26(7) |
| ISSN: | 1744-5078 |
| Popis: | To assess the outcomes of intravitreal benzyl alcohol-free triamcinolone acetonide suspension in uveitis-related macular oedema.Single-center retrospective cohort study of 66 injections to 44 eyes of 40 patients. Uveitis diagnosis, systemic and local therapy, intraocular pressure (IOP), central retinal thickness (CRT), number of injections, time to re-injection and side-effects were noted during 6-months minimum follow-up.Sixty eight percent of eyes received a single injection. 18% required 2 injections, and 13% received ≥3 injections with mean time to second and third injections of 25.5 and 52.7 weeks, respectively. 90% of injections were unilateral. Mean CRT reduced, and by 12-weeks visual acuity improvement0.3logMar was achieved in 46%. Cataract progression (47%) and IOP21 mmHg (45%) were the commonest adverse events.Preservative-free triamcinolone is an additional option for uveitis-related macular oedema, particularly in unilateral cases, with favorable CRT and visual outcomes. Repeat injections may be necessary, and the period of efficacy varies between eyes. |
| Databáze: | OpenAIRE |
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