Impairment in exploratory behavior is associated with arc gene overexpression in the dorsolateral striatum of rats with nigral injection of l-buthionine sulfoximine
| Autor: | E. Alberti-Amador, J.L. Ruiz-Fuentes, A. Díaz-García, N. Pavón-Fuentes, L. Blanco-Lezcano, R. León-Martínez, M.L. Díaz-Hung |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Gene Expression Nerve Tissue Proteins Biology Open field Rats Sprague-Dawley Random Allocation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Basal ganglia medicine Animals Buthionine Sulfoximine Gene Injections Intraventricular Arc (protein) Pars compacta General Neuroscience Glutathione L-Buthionine sulfoximine Corpus Striatum Rats Substantia Nigra Cytoskeletal Proteins 030104 developmental biology Endocrinology nervous system chemistry Synaptic plasticity Exploratory Behavior 030217 neurology & neurosurgery |
| Zdroj: | Neuroscience Letters. 687:26-30 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/j.neulet.2018.09.026 |
| Popis: | The aims of the present work were to evaluate the exploratory activity in Sprague-Dawley rats, as well as to analyze the nigral and striatal mRNA expression of the plasticity-related genes bdnf and arc after L-buthionine sulfoximine (BSO) injection into substantia nigra compacta. Lesioned rats traveled less distance in open field but did not show a decline in the novel object recognition test. On the other hand, RT-PCR analysis showed overexpression of striatal arc 24 h post-lesion; no significant changes in bdnf expression were observed in nigral or striatal tissue. These results suggest that intranigral BSO injection causes impairment in exploratory behavior in these rats, by affecting locomotion, which is associated with changes in striatal synaptic plasticity. |
| Databáze: | OpenAIRE |
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