Regulatory T Cells: An Emerging Player in Radiation-Induced Lung Injury

Autor: Tiantian Guo, Liqing Zou, Jianjiao Ni, Yue Zhou, Luxi Ye, Xi Yang, Zhengfei Zhu
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
lcsh:Immunologic diseases. Allergy
Epithelial-Mesenchymal Transition
Mini Review
medicine.medical_treatment
Pulmonary Fibrosis
Immunology
Inflammation
chemical and pharmacologic phenomena
Lung injury
medicine.disease_cause
T-Lymphocytes
Regulatory
Autoimmunity
lung
03 medical and health sciences
0302 clinical medicine
Immune system
Th2 Cells
medicine
Immunology and Allergy
Animals
Humans
Th1-Th2 Balance
radiotherapy
business.industry
fibrosis
pneumonitis
Immunosuppression
hemic and immune systems
Immunotherapy
Lung Injury
Th1 Cells
medicine.disease
Radiation therapy
Radiation Pneumonitis
Treg
030104 developmental biology
Phenotype
Radiation-induced lung injury
Cancer research
Cytokines
Th17 Cells
medicine.symptom
business
lcsh:RC581-607
030215 immunology
Signal Transduction
Zdroj: Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology
ISSN: 1664-3224
Popis: Regulatory T cells (Tregs), which have long been recognized as essential regulators of both inflammation and autoimmunity, also impede effective antitumor immune response due to their immunosuppressive properties. Combined radiotherapy and immunotherapeutic interventions focusing on the removal of Tregs have recently garnered interest as a promising strategy to reverse immunosuppression. Meanwhile, Tregs are emerging as a key player in the pathogenesis of radiation-induced lung injury (RILI), a frequent and potentially life-threatening complication of thoracic radiotherapy. Recognition of the critical role of Tregs in RILI raises the important question of whether radiotherapy combined with Treg-targeting immunotherapy offers any beneficial effects in the protection of normal lung tissue. This present review focuses on the contributions of Tregs to RILI, with particular emphasis on the suspected differential role of Tregs in the pneumonitic phase and fibrotic phase of RILI. We also introduce recent progress on the potential mechanisms by which Tregs modulate RILI and the crosstalk among Tregs, other infiltrating T cells, fibrocytes, and resident epithelial cells driving disease pathogenesis. Finally, we discuss whether Tregs also hold promise as a potential target for immunotherapeutic interventions for RILI.
Databáze: OpenAIRE
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