Airway responsiveness to sulfur dioxide in an adult population sample
| Autor: | Jürgen Berger, Helgo Magnussen, Matthias Claussen, Rudolf A. Jörres, Dennis Nowak |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male Provocation test Population Physiology Critical Care and Intensive Care Medicine complex mixtures Bronchial Provocation Tests Atopy Bronchoconstrictor Agents Random Allocation Predictive Value of Tests Reference Values Risk Factors Surveys and Questionnaires Hyperventilation Prevalence Respiratory Hypersensitivity Medicine Humans Sulfur Dioxide Respiratory system education Methacholine Chloride education.field_of_study Air Pollutants Inhalation Dose-Response Relationship Drug business.industry medicine.disease Confidence interval respiratory tract diseases Spirometry Anesthesia Regression Analysis Methacholine Female medicine.symptom business medicine.drug |
| Zdroj: | American journal of respiratory and critical care medicine. 156(4 Pt 1) |
| ISSN: | 1073-449X |
| Popis: | We determined the prevalence of airway hyperresponsiveness to sulfur dioxide (SO2) in an adult population sample of 790 subjects 20 to 44 yr of age. Subjects were drawn randomly from the population of Hamburg, Northern Germany, within the framework of the European Community Respiratory Health Survey. In addition, we analyzed the relationship between SO2 responsiveness and a number of risk factors, such as a history of respiratory symptoms, methacholine responsiveness, and atopy derived from skin-prick test results. SO2 inhalation challenges were performed during isocapnic hyperventilation at constant rate (40 L x min(-1), for 3 min) with doubling concentrations of SO2 up to a maximum concentration of 2.0 ppm. If subjects achieved a 20% decrease in FEV1 from baseline during the challenge, they were considered to be hyperresponsive to SO2. The raw prevalence of SO2 hyperresponsiveness within the population sample studied was 3.4% (95% confidence interval [CI]: 2.3 to 5.0%). Adjustment for nonparticipation led to an estimated prevalence of SO2 hyperresponsiveness of 5.4%. Among subjects with hyperresponsiveness to methacholine, 22.4% (95% CI: 20.1 to 25.3) demonstrated hyperresponsiveness to SO2. There was no significant correlation between the degrees of hyperresponsiveness to methacholine and SO2. Predictors of a positive SO2 response were hyperresponsiveness to methacholine (p0.0001), a positive history of respiratory symptoms (p0.05), and a positive skin-prick test to at least one common allergen (p0.05). We conclude from these data that airway hyperresponsiveness to SO2 can be found in about 20 to 25% of subjects within the 20- to 44-yr age range who are hyperresponsive to methacholine. |
| Databáze: | OpenAIRE |
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