Impulsivity Relates to Relative Preservation of Mesolimbic Connectivity in Patients with Parkinson Disease

Autor: Jasmine A T DiCesare, Collin M. Price, Hannah Riskin-Jones, Nadia Hashoush, Ausaf A. Bari, Hiro Sparks, Nader Pouratian
Rok vydání: 2020
Předmět:
Male
Aging
Impulse control disorder
medicine.medical_treatment
Neurodegenerative
lcsh:RC346-429
Neural Pathways
2.1 Biological and endogenous factors
Aetiology
Parkinson's Disease
Dopaminergic
Regular Article
Parkinson Disease
Middle Aged
diffusion tensor imaging
Magnetic Resonance Imaging
Substantia Nigra
Mental Health
Neurology
Neurological
lcsh:R858-859.7
Biomedical Imaging
Female
medicine.symptom
medicine.drug
Deep brain stimulation
Cognitive Neuroscience
impulsivity
Context (language use)
Substantia nigra
Impulsivity
lcsh:Computer applications to medicine. Medical informatics
Basic Behavioral and Social Science
Reward
Dopamine
Clinical Research
Behavioral and Social Science
medicine
Humans
Radiology
Nuclear Medicine and imaging
lcsh:Neurology. Diseases of the nervous system
Aged
business.industry
Neurosciences
medicine.disease
Brain Disorders
nervous system
impulse control disorder
Impulsive Behavior
Neurology (clinical)
business
Neuroscience
Diffusion MRI
Zdroj: NeuroImage : Clinical
NeuroImage: Clinical, Vol 27, Iss, Pp 102259-(2020)
Popis: Highlights • Probabilistic tractography can identify functional subsegments of substantia nigra • Topographic organization of subsegments is preserved in Parkinson patients • Relative limbic-substantia nigra connectivity strength is associated with impulsivity • Relative volume of substantia nigra subsegments is not associated with impulsivity
Introduction The relationship between Parkinson Disease (PD) pathology, dopamine replacement therapy (DRT), and impulse control disorder (ICD) development is still incompletely understood. Given the sensorimotor-lateral substantia nigra (SN) selective degeneration associated with PD, we posit that a relative sparing of the limbic-medial SN in the context of DRT drives impulsive, reward-seeking behavior in PD patients with recent history of severe impulsivity. Methods Impulsive and control participants were selected from a consecutive list of PD patients receiving pre-operative deep brain stimulation (DBS) planning scans including 3T structural MRI and 64 direction diffusion tensor imaging (DTI). Using previously identified substantia nigra (SN) subsegment network connectivity profiles to develop classification targets, split-hemisphere target-based SN segmentation with probabilistic tractography was performed. The relative subsegment volumes and strength of connectivity between the SN and the limbic, associative, and motor network targets were compared. Results Our results show that there is greater probability of connectivity between the SN and limbic network targets relative to motor and associative network targets in PD patients with recent history of severe impulsivity as compared to PD patients without impulsivity (P = 0.0075). We did not observe relative volumetric subsegment differences across groups. Conclusion Firstly, our results suggest that fine-grained, atlas-derived classification targets may be used in PD to parcellate and classify functionally distinct subsegments of the SN, with the apparent preservation of previously reported topographical limbic-medial SN, associative-ventral SN, and sensorimotor-lateral SN orientation. We suggest that relative, as opposed to absolute, degeneration amongst SN-associated dopaminergic networks relates to the impulsivity phenotype in PD.
Databáze: OpenAIRE
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