Long-term clinical observation of the immunogenicity of inactivated hepatitis A vaccine in children
| Autor: | Guozhang Xu, Yong-Xin Lin, Guo-lin Bian, Yao-rong Chen, Hongjun Dong, Shao-ying Zhou, Hongxia Ni, Jia-Qun Chen, Fengjiao Hu, Rui Ma |
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| Rok vydání: | 2010 |
| Předmět: |
Male
China Hepatitis A vaccine Enzyme-Linked Immunosorbent Assay Antibodies Viral Hepatitis A Antibodies Vaccines Attenuated Antigen medicine Humans Child Hepatitis A Vaccines Models Statistical General Veterinary General Immunology and Microbiology biology business.industry Immunogenicity Vaccination Public Health Environmental and Occupational Health Infant Hepatitis A medicine.disease Infectious Diseases Vaccines Inactivated Immunization Child Preschool Immunology biology.protein Molecular Medicine Female Antibody Viral hepatitis business Immunologic Memory Follow-Up Studies |
| Zdroj: | Vaccine. 28:4798-4801 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/j.vaccine.2010.04.096 |
| Popis: | 110 children who were given the complete course of the inactivated hepatitis A vaccine (Havrix) were followed up 10 years later. Age-matched healthy children who were not inoculated served as controls. One month after two primary injections, all children were positive for serum antibody. After 10 years, 99.09% of inoculated children remained positive for serum anti-HAV antibody, with a geometric mean concentration (GMC) of 61.59mIU/mL. GMC values following a secondary immunization in children with antibody levels20mIU/mL were significantly elevated (567.9mIU/mL), compared with the primary injection alone. Havrix appears to induce persistent immunity and potent immune memory. |
| Databáze: | OpenAIRE |
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