Synthesis of Kisspeptin-Mimicking Fragments and Investigation of their Skin Anti-Aging Effects

Autor: Hyo Hyun Seo, Myeong Sam Park, Seoyeon Kyung, Seunghyun Kang, Jeong Su-Gyeong, Seok Kyun Yun, Sang Hyun Moh, Abadie Sophie, Hyeonju Yeo, Kyung-Eun Lee
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Models
Molecular
collagen
Protein Conformation
Gene Expression
Stimulation
Human skin
Skin Aging
Tissue Culture Techniques
lcsh:Chemistry
030207 dermatology & venereal diseases
0302 clinical medicine
Kisspeptin
Skin Physiological Phenomena
11-beta-Hydroxysteroid Dehydrogenase Type 1
11β-HSD1
lcsh:QH301-705.5
Spectroscopy
Skin
Kisspeptins
Molecular Structure
integumentary system
MMP-1
Biological activity
General Medicine
Computer Science Applications
Cell biology
Matrix Metalloproteinase 1
hormones
hormone substitutes
and hormone antagonists
Ultraviolet Rays
Neuropeptide
Biology
Models
Biological
Catalysis
Article
Collagen Type I
Kisspeptin-mimicking fragments
Cell Line
Inorganic Chemistry
03 medical and health sciences
Humans
Secretion
RNA
Messenger
Physical and Theoretical Chemistry
Molecular Biology
skin aging
Solid-Phase Synthesis Techniques
Interleukin-6
Organic Chemistry
Interleukin-8
Molecular Mimicry
Fibroblasts
Peptide Fragments
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
Hormone
Zdroj: International Journal of Molecular Sciences
Volume 21
Issue 22
International Journal of Molecular Sciences, Vol 21, Iss 8439, p 8439 (2020)
ISSN: 1422-0067
DOI: 10.3390/ijms21228439
Popis: In recent years, a number of active materials have been developed to provide anti-aging benefits for skin and, among them, peptides have been considered the most promising candidate due to their remarkable and long-lasting anti-wrinkle activity. Recent studies have begun to elucidate the relationship between the secretion of emotion-related hormones and skin aging. Kisspeptin, a neuropeptide encoded by the KISS1 gene, has gained attention in reproductive endocrinology since it stimulates the reproductive axis in the hypothalamus
however, the effects of Kisspeptin on skin have not been studied yet. In this study, we synthesized Kisspeptin-10 and Kisspeptin-E, which are biologically active fragments, to mimic the action of Kisspeptin. Next, we demonstrated the anti-aging effects of the Kisspeptin-mimicking fragments using UV-induced skin aging models, such as UV-induced human dermal fibroblasts (Hs68) and human skin explants. Kisspeptin-E suppressed UV-induced 11 beta-hydroxysteroid dehydrogenase type 1 (11&beta
HSD1) stimulation leading to a regulation of skin aging related genes, including type I procollagen, matrix metalloproteinases-1 (MMP-1), interleukin-6 (IL-6), and IL-8, and rescued the skin integrity. Taken together, these results suggest that Kisspeptin-E could be useful to improve UV-induced skin aging by modulating expression of stress related genes, such as 11&beta
HSD1.
Databáze: OpenAIRE
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