Distribution of111 in-bleomycin complex in small cell lung cancer cells by autoradiography
| Autor: | Yosh Maruyama, De-Yan Hou |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Cytoplasm
Pathology medicine.medical_specialty Lung Neoplasms medicine.medical_treatment Cell Bleomycin Indium chemistry.chemical_compound Tumor Cells Cultured medicine Humans Distribution (pharmacology) Carcinoma Small Cell Nuclear membrane Cell Nucleus Chemotherapy business.industry Indium Radioisotopes General Medicine respiratory tract diseases Cell nucleus medicine.anatomical_structure Oncology Mechanism of action chemistry Autoradiography Surgery medicine.symptom business |
| Zdroj: | Journal of Surgical Oncology. 49:93-97 |
| ISSN: | 1096-9098 0022-4790 |
| DOI: | 10.1002/jso.2930490206 |
| Popis: | The distribution of 111 In-bleomycin Complex (111In-BLMC) in small cell lung cancer (SCLC) cells was studied by autoradiography. SCLC cells were exposed to 111In-BLMC and 111Indium chloride (111InCl3) for 1 hour, 3 hours, and 4 hours; washed with fresh medium; and spread on slides. The slides were smeared with NTB2. (NTB3) emulsion by wet or dry-mount technique and exposed 3 to 15 days. 111In-BLMC was found to localize in the cell nucleus and nuclear membrane (78.3%); 111InCl3 located mainly in the cytoplasm (52.3%). This distribution of labeled BLM may explain the mechanism of killing SCLC cells by 111In-BLMC. |
| Databáze: | OpenAIRE |
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