Fel d1 Blocking Antibodies: A Novel Method to Reduce IgE-Mediated Allergy to Cats
| Autor: | Scott Sherrill, Peichuan Sun, Ebenezer Satyaraj |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Hypersensitivity
Immediate Article Subject medicine.medical_treatment Immunology Basophil degranulation Immunoglobulin E medicine.disease_cause Cell Degranulation 03 medical and health sciences 0302 clinical medicine Allergen Cell Line Tumor Blocking antibody medicine Immunology and Allergy Animals Humans 030212 general & internal medicine Antibodies Blocking Saliva Glycoproteins biology Allergy to cats business.industry General Medicine Immunotherapy Pets Allergens RC581-607 Basophils Rats 030228 respiratory system Polyclonal antibodies biology.protein Cats Rabbits Antibody Immunologic diseases. Allergy business Chickens Research Article |
| Zdroj: | Journal of Immunology Research, Vol 2021 (2021) Journal of Immunology Research |
| ISSN: | 2314-8861 |
| DOI: | 10.1155/2021/5545173 |
| Popis: | Fel d1 is an important allergen produced by cats that causes IgE reactions in up to 95% of cat-allergic adults. Immunotherapy to reduce human allergy to cats has demonstrated that people have the capacity to produce allergen-specific neutralizing antibodies that block IgE-mediated allergic responses. We wished to determine if “blocking” antibodies could be used to reduce the IgE binding ability of cat allergens prior to their exposure to humans. Here, we describe the characterization of Fel d1-specific antibodies. We demonstrated the efficacy of a rabbit polyclonal and an allergen-specific chicken IgY to bind to Fel d1 in cat saliva and block Fel d1-IgE binding and IgE-mediated basophil degranulation. Fel d1 blocking antibodies offer a new and exciting approach to the neutralization of cat allergens. |
| Databáze: | OpenAIRE |
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