Long-term Management of Panuveitis and Choroidal Mass Associated with Rosai Dorfman Disease with Pegylated Interferon
| Autor: | Jessica G. Shantha, Steven Yeh, Hans E. Grossniklaus, Lucas Kim, Anastasios P. Costarides, J. Clay Bavinger |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Systemic disease Disease Antiviral Agents Systemic therapy Article Polyethylene Glycols 03 medical and health sciences 0302 clinical medicine Pegylated interferon Panuveitis medicine Humans Immunology and Allergy Topical Steroid Therapy Histiocyte Rosai–Dorfman disease 030203 arthritis & rheumatology business.industry Middle Aged medicine.disease Dermatology eye diseases Ophthalmology 030221 ophthalmology & optometry Female Steroids Interferons sense organs Histiocytosis Sinus business medicine.drug |
| Zdroj: | Ocul Immunol Inflamm |
| ISSN: | 1744-5078 0927-3948 |
| Popis: | Purpose: To present a patient with Rosai-Dorfman Disease (RDD), a histiocytic proliferative disorder typified by lymphadenopathy with rare ocular manifestations, who developed panuveitis that responded to pegylated interferon.Methods: Descriptive case report of a patient with RDD with multi-organ involvement including ocular manifestations including bilateral panuveitis with choroidal masses.Results: A 54-year-old African American woman with known systemic RDD of the breast, lung, and gastrointestinal tract presented with panuveitis with choroidal masses in both eyes. Her systemic and ocular disease initially responded well to oral and topical steroid therapy. Later, however, her systemic disease progressed with multiple muscular and bony lesions. Systemic therapy was switched to pegylated interferon, a cytokine with antiviral, antitumor and immunomodulatory activity. After 14 months of therapy with pegylated interferon, the patient's systemic and ocular disease stabilized.Conclusion: Rosai-Dorfman disease may be complicated by panuveitis and choroidal masses that may respond to pegylated interferon with stabilization of systemic and ocular manifestations. A multi-disciplinary approach is essential given the unique diagnostic and management challenges of RDD. |
| Databáze: | OpenAIRE |
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