Sevoflurane degradation by soda lime in a circle breathing system
| Autor: | I T, Munday, P M, Ward, N D, Foden, R M, Jones, F N, Van Pelt, J G, Kenna |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Methyl Ethers Hydrocarbons Fluorinated Expiratory limb Positive correlation complex mixtures Sevoflurane Drug Administration Schedule chemistry.chemical_compound Soda lime Anesthesia Closed-Circuit medicine Humans Sodium Hydroxide Chromatography business.industry Temperature Breathing system Oxides Calcium Compounds Anesthesiology and Pain Medicine chemistry Sodium hydroxide Anesthesia Anesthetics Inhalation Degradation (geology) Gas chromatography business medicine.drug Ethers |
| Zdroj: | Anaesthesia. 51(7) |
| ISSN: | 0003-2409 |
| Popis: | Sevoflurane is degraded by soda lime to a vinyl ether commonly referred to as compound A. We measured the concentration of compound A in the circle breathing system of 31 patients receiving sevoflurane anaesthesia. Inspiratory and expiratory gas samples were analysed using gas chromatography and flame ionisation detection. The end-tidal sevoflurane concentration and soda lime temperature were recorded. The peak compound A concentration ranged between 10 to 32 ppm in the inspiratory limb and 7 to 26 ppm in the expiratory limb. There was a positive correlation between the peak compound A concentration and the end-tidal sevoflurane concentration (r2 = 0.545, p < 0.0001) and the soda lime temperature (r2 = 0.301, p = 0.0014). We conclude that the end-tidal concentration of sevoflurane and the temperature of the soda lime are important variables in determining concentration of compound A in a circle system. |
| Databáze: | OpenAIRE |
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